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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3A
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pubmed:dateCreated |
1999-9-20
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pubmed:abstractText |
Irinotecan (CPT-11) is hydrolyzed by carboxyl esterase to the active metabolite SN-38 and oral irinotecan could undergo intestinal and hepatic activation. MATERNALS AND METHODS: Irinotecan was incubated with S9 fractions of human liver and intestinal tissues and the specific activity was determined based on the formation rate of SN-38.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2067-71
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pubmed:dateRevised |
2007-9-25
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pubmed:meshHeading |
pubmed-meshheading:10470149-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10470149-Biotransformation,
pubmed-meshheading:10470149-Camptothecin,
pubmed-meshheading:10470149-Carboxylic Ester Hydrolases,
pubmed-meshheading:10470149-Colon,
pubmed-meshheading:10470149-Duodenum,
pubmed-meshheading:10470149-Humans,
pubmed-meshheading:10470149-Hydrolysis,
pubmed-meshheading:10470149-Ileum,
pubmed-meshheading:10470149-Intestinal Mucosa,
pubmed-meshheading:10470149-Intestinal Neoplasms,
pubmed-meshheading:10470149-Intestines,
pubmed-meshheading:10470149-Jejunum,
pubmed-meshheading:10470149-Liver Neoplasms,
pubmed-meshheading:10470149-Microsomes,
pubmed-meshheading:10470149-Microsomes, Liver,
pubmed-meshheading:10470149-Neoplasm Proteins,
pubmed-meshheading:10470149-Organ Specificity,
pubmed-meshheading:10470149-Prodrugs,
pubmed-meshheading:10470149-Rectum
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pubmed:articleTitle |
In vitro activation of irinotecan to SN-38 by human liver and intestine.
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pubmed:affiliation |
Department of Pharmacology, Robert Wood Johnson Medical School, New Jersey, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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