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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-5-9
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pubmed:abstractText |
Polycystic ovary syndrome (PCOS) is a form of functional ovarian hyperandrogenism and affects approximately 5-10% of women of reproductive age. Insulin resistance and hyperinsulinaemia appear to be almost universal feature of the polycystic ovary syndrome. Abnormal regulation of cytochrome P450c17alpha causes the exaggerated secretion of ovarian androgens in PCOS. The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10468995-17-alpha-Hydroxyprogesterone,
pubmed-meshheading:10468995-Adult,
pubmed-meshheading:10468995-Androstenedione,
pubmed-meshheading:10468995-Buserelin,
pubmed-meshheading:10468995-Case-Control Studies,
pubmed-meshheading:10468995-Female,
pubmed-meshheading:10468995-Follicle Stimulating Hormone,
pubmed-meshheading:10468995-Glucose Tolerance Test,
pubmed-meshheading:10468995-Humans,
pubmed-meshheading:10468995-Hyperinsulinism,
pubmed-meshheading:10468995-Hypoglycemic Agents,
pubmed-meshheading:10468995-Insulin Resistance,
pubmed-meshheading:10468995-Luteinizing Hormone,
pubmed-meshheading:10468995-Metformin,
pubmed-meshheading:10468995-Polycystic Ovary Syndrome,
pubmed-meshheading:10468995-Statistics, Nonparametric
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pubmed:year |
1999
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pubmed:articleTitle |
The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome.
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pubmed:affiliation |
Departments of Endocrinology, Erciyes University School of Medicine, Kayseri, Turkey.
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pubmed:publicationType |
Journal Article
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