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| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C1417890 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C1709287 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:10468633 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:10468633 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:10468633 | pubmed:dateCreated | 1999-10-7 | lld:pubmed |
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| pubmed-article:10468633 | pubmed:abstractText | Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differentiation (but not proliferation) is promoted by human NUMB protein isoforms with a type I (short) PRR. In contrast, proliferation (but not differentiation) is directed by isoforms that have a type II (long) PRR. The two types of PRR may promote distinct intracellular signaling pathways downstream of the NOTCH receptor during mammalian neurogenesis. | lld:pubmed |
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| pubmed-article:10468633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10468633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10468633 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10468633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10468633 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10468633 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:MeakinS OSO | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:VerdiJ MJM | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:LipshitzH DHD | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:JamaliMM | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:GoldhawkD EDE | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:BashirullahAA | lld:pubmed |
| pubmed-article:10468633 | pubmed:author | pubmed-author:KENTPP | lld:pubmed |
| pubmed-article:10468633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10468633 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:10468633 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10468633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10468633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10468633 | pubmed:pagination | 10472-6 | lld:pubmed |
| pubmed-article:10468633 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10468633 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10468633 | pubmed:articleTitle | Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. | lld:pubmed |
| pubmed-article:10468633 | pubmed:affiliation | Robarts Research Institute, London, ON N6A 5K8, Canada. | lld:pubmed |
| pubmed-article:10468633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10468633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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