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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1999-10-7
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pubmed:databankReference |
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pubmed:abstractText |
Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differentiation (but not proliferation) is promoted by human NUMB protein isoforms with a type I (short) PRR. In contrast, proliferation (but not differentiation) is directed by isoforms that have a type II (long) PRR. The two types of PRR may promote distinct intracellular signaling pathways downstream of the NOTCH receptor during mammalian neurogenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-10065155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-1458542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-1557121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-2194165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-2517255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-2752427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-6656766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-7690960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-7707973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-7956822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-7993627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8313469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8507558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8755476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8755477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8805372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-8845150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-9245493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-9608510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-9632782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-9892564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10468633-9920832
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10472-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10468633-Alternative Splicing,
pubmed-meshheading:10468633-Amino Acid Sequence,
pubmed-meshheading:10468633-Animals,
pubmed-meshheading:10468633-Animals, Genetically Modified,
pubmed-meshheading:10468633-Cell Differentiation,
pubmed-meshheading:10468633-Cell Division,
pubmed-meshheading:10468633-Cell Line,
pubmed-meshheading:10468633-Drosophila,
pubmed-meshheading:10468633-Drosophila Proteins,
pubmed-meshheading:10468633-Humans,
pubmed-meshheading:10468633-Juvenile Hormones,
pubmed-meshheading:10468633-Molecular Sequence Data,
pubmed-meshheading:10468633-Multigene Family,
pubmed-meshheading:10468633-Neurons,
pubmed-meshheading:10468633-Protein Isoforms,
pubmed-meshheading:10468633-RNA, Messenger,
pubmed-meshheading:10468633-Transcription, Genetic,
pubmed-meshheading:10468633-Transfection,
pubmed-meshheading:10468633-Wing
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pubmed:year |
1999
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pubmed:articleTitle |
Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.
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pubmed:affiliation |
Robarts Research Institute, London, ON N6A 5K8, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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