10467245

Source:http://linkedlifedata.com/resource/pubmed/id/10467245

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0443288, umls-concept:C0927232, umls-concept:C1709634
pubmed:issue	4
pubmed:dateCreated	1999-10-12
pubmed:abstractText	Acquisition of cell type-specific properties in the nervous system is likely a process of sequential restriction in developmental potential. At least two classes of pluripotent stem cells, neuroepithelial (NEP) stem cells and EGF-dependent neurosphere stem cells, have been identified in distinct spatial and temporal domains. Pluripotent stem cells likely generate central nervous system (CNS) and peripheral nervous system (PNS) derivatives via the generation of intermediate lineage-restricted precursors that differ from each other and from multipotent stem cells. Neuronal precursors termed neuronal-restricted precursors (NRPs), multiple classes of glial precursors termed glial-restricted precursors (GRPs), oligodendrocyte-type 2 astrocytes (O2As), astrocyte precursor cells (APCs), and PNS precursors termed neural crest stem cells (NCSCs) have been identified. Multipotent stem cells and restricted precursor cells can be isolated from embryonic stem (ES) cell cultures providing a non-fetal source of such cells. Analysis in multiple species illustrates similarities between rat, mouse, and human cell differentiation raising the possibility that similar factors and markers may be used to isolate precursor cells from human tissue or ES cells. Anat Rec (New Anat): 257:137-143, 1999.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/10467245-10944574
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370540
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0003-276X
pubmed:author	pubmed-author:RaoM SMS
pubmed:copyrightInfo	Copyright 1999 Wiley-Liss, Inc.
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	257
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	137-48
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:10467245-Animals, pubmed-meshheading:10467245-Central Nervous System, pubmed-meshheading:10467245-Humans, pubmed-meshheading:10467245-Mice, pubmed-meshheading:10467245-Rats, pubmed-meshheading:10467245-Stem Cells
pubmed:year	1999
pubmed:articleTitle	Multipotent and restricted precursors in the central nervous system.
pubmed:affiliation	Department of Neurobiology and Anatomy, University of Utah Medical School, Salt Lake City 84132, USA. Mahendra.Rao@hsc.utah.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't