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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-9-14
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pubmed:abstractText |
The effects of pyrethroid pesticides (deltamethrin, permethrin and cypermethrin) and an organophosphate ester (methidation) on the activities of carp trypsin, alpha-chymotrypsin, carboxypeptidase A and lipase were studied. The enzymes were isolated from the gastrointestinal tract and the effects of the pesticides were investigated during incubation for 5 min. The activity of trypsin was influenced only slightly by the presence of deltamethrin and methidation, whereas permethrin and cypermethrin caused significant inhibition. The pyrethroid pesticides at lower concentrations resulted in a slight activation of alpha-chymotrypsin. Methidation inhibited the alpha-chymotrypsin activity by about 20%. These pesticides modified the lipase activity to a lesser extent; the highest inhibition was measured with cypermethrin. The carboxypeptidase A activity was inhibited by both pyrethroid pesticides and methidation. The results suggest that these pesticides might interact with the active conformation of the studied hydrolytic enzymes, resulting in changes in their activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carboxypeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Carboxypeptidases A,
http://linkedlifedata.com/resource/pubmed/chemical/Chymotrypsin,
http://linkedlifedata.com/resource/pubmed/chemical/Industrial Waste,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Organothiophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Permethrin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrethrins,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin,
http://linkedlifedata.com/resource/pubmed/chemical/cypermethrin,
http://linkedlifedata.com/resource/pubmed/chemical/decamethrin,
http://linkedlifedata.com/resource/pubmed/chemical/methidathion
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0360-1234
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
819-28
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pubmed:dateRevised |
2009-7-21
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pubmed:meshHeading |
pubmed-meshheading:10466103-Animals,
pubmed-meshheading:10466103-Carboxypeptidases,
pubmed-meshheading:10466103-Carboxypeptidases A,
pubmed-meshheading:10466103-Carps,
pubmed-meshheading:10466103-Chymotrypsin,
pubmed-meshheading:10466103-Digestion,
pubmed-meshheading:10466103-Industrial Waste,
pubmed-meshheading:10466103-Insecticides,
pubmed-meshheading:10466103-Lipase,
pubmed-meshheading:10466103-Nitriles,
pubmed-meshheading:10466103-Organothiophosphorus Compounds,
pubmed-meshheading:10466103-Permethrin,
pubmed-meshheading:10466103-Pyrethrins,
pubmed-meshheading:10466103-Trypsin,
pubmed-meshheading:10466103-Water Pollution, Chemical
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pubmed:year |
1999
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pubmed:articleTitle |
Effects of synthetic pyrethroids and methidation on activities of some digestive enzymes in carp (Cyprinus carpio L.).
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pubmed:affiliation |
Department of Biochemistry, József Attila University, Szeged, Hungary.
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pubmed:publicationType |
Journal Article
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