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rdf:type |
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lifeskim:mentions |
umls-concept:C0022181,
umls-concept:C0022947,
umls-concept:C0205177,
umls-concept:C0205531,
umls-concept:C0205549,
umls-concept:C0226896,
umls-concept:C0268563,
umls-concept:C0442027,
umls-concept:C1257954,
umls-concept:C1527415,
umls-concept:C1880355,
umls-concept:C1956166
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pubmed:issue |
15
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pubmed:dateCreated |
1999-11-24
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pubmed:abstractText |
Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BoyceSS,
pubmed-author:BrideauCC,
pubmed-author:ChanC CCC,
pubmed-author:CharlesonSS,
pubmed-author:GordonRR,
pubmed-author:GrimmEE,
pubmed-author:GubaAA,
pubmed-author:LégerSS,
pubmed-author:LeblancYY,
pubmed-author:LiC SCS,
pubmed-author:PrasitPP,
pubmed-author:RiendeauDD,
pubmed-author:RoyPP,
pubmed-author:ViscoDD,
pubmed-author:WangZZ,
pubmed-author:WebbJJ,
pubmed-author:YUL KLK
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2207-12
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10465547-Administration, Oral,
pubmed-meshheading:10465547-Animals,
pubmed-meshheading:10465547-Cyclooxygenase 2,
pubmed-meshheading:10465547-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:10465547-Cyclooxygenase Inhibitors,
pubmed-meshheading:10465547-Humans,
pubmed-meshheading:10465547-Isoenzymes,
pubmed-meshheading:10465547-Macaca mulatta,
pubmed-meshheading:10465547-Membrane Proteins,
pubmed-meshheading:10465547-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10465547-Rats,
pubmed-meshheading:10465547-Saimiri,
pubmed-meshheading:10465547-Structure-Activity Relationship,
pubmed-meshheading:10465547-U937 Cells
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pubmed:year |
1999
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pubmed:articleTitle |
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.
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pubmed:affiliation |
Merck Frosst Centre for Therapeutic Research, Québec, Canada.
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pubmed:publicationType |
Journal Article
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