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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1999-11-24
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pubmed:abstractText |
Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cnr2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cannabinoid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrocannabinol,
http://linkedlifedata.com/resource/pubmed/chemical/delta-8-tetrahydrocannabinol
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2119-24
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pubmed:dateRevised |
2009-9-4
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pubmed:meshHeading |
pubmed-meshheading:10465529-Animals,
pubmed-meshheading:10465529-Brain,
pubmed-meshheading:10465529-Cell Membrane,
pubmed-meshheading:10465529-Mice,
pubmed-meshheading:10465529-Rats,
pubmed-meshheading:10465529-Receptor, Cannabinoid, CB2,
pubmed-meshheading:10465529-Receptors, Cannabinoid,
pubmed-meshheading:10465529-Receptors, Drug,
pubmed-meshheading:10465529-Spleen,
pubmed-meshheading:10465529-Structure-Activity Relationship,
pubmed-meshheading:10465529-Tetrahydrocannabinol
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pubmed:year |
1999
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pubmed:articleTitle |
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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