Source:http://linkedlifedata.com/resource/pubmed/id/10464172
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1999-12-7
|
| pubmed:abstractText |
Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey-mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3(-)CD4(+)CD8(-) thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. The data suggest that in patients infected with HIV, T cell maturation and thus replenishment of peripheral pools may be compromised as a result of intrathymic infection or circulating viral gp120.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0953-8178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1509-18
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10464172-Animals,
pubmed-meshheading:10464172-Antigens, CD,
pubmed-meshheading:10464172-Cell Differentiation,
pubmed-meshheading:10464172-Cell Separation,
pubmed-meshheading:10464172-Cells, Cultured,
pubmed-meshheading:10464172-Dose-Response Relationship, Immunologic,
pubmed-meshheading:10464172-HIV Envelope Protein gp120,
pubmed-meshheading:10464172-Immunity, Cellular,
pubmed-meshheading:10464172-Lymphocyte Count,
pubmed-meshheading:10464172-Macaca mulatta,
pubmed-meshheading:10464172-Mice,
pubmed-meshheading:10464172-Mice, Inbred BALB C,
pubmed-meshheading:10464172-Polymerase Chain Reaction,
pubmed-meshheading:10464172-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10464172-Simian immunodeficiency virus,
pubmed-meshheading:10464172-T-Lymphocyte Subsets,
pubmed-meshheading:10464172-Thymus Gland
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Impaired thymopoietic potential of immature CD3(-)CD4(+)CD8(-) T cell precursors from SIV-infected rhesus monkeys.
|
| pubmed:affiliation |
Institute of Virology and Immunobiology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|