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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-9-16
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pubmed:abstractText |
Nitric oxide (NO)-releasing derivatives of cyclooxygenase inhibitors exhibit enhanced anti-inflammatory activity and greatly reduced gastrointestinal toxicity. We evaluated whether a similar derivatization of mesalamine (5-aminosalicylic acid) would improve its anti-inflammatory activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminosalicylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mesalamine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
557-66
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10464131-Aminosalicylic Acids,
pubmed-meshheading:10464131-Animals,
pubmed-meshheading:10464131-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:10464131-Caspase 1,
pubmed-meshheading:10464131-Cell Adhesion,
pubmed-meshheading:10464131-Cells, Cultured,
pubmed-meshheading:10464131-Chemotaxis, Leukocyte,
pubmed-meshheading:10464131-Colitis,
pubmed-meshheading:10464131-Colon,
pubmed-meshheading:10464131-Disease Models, Animal,
pubmed-meshheading:10464131-Endothelium, Vascular,
pubmed-meshheading:10464131-Interferon-gamma,
pubmed-meshheading:10464131-Interleukin-1,
pubmed-meshheading:10464131-Leukocytes,
pubmed-meshheading:10464131-Male,
pubmed-meshheading:10464131-Mesalamine,
pubmed-meshheading:10464131-Nitric Oxide,
pubmed-meshheading:10464131-Nitric Oxide Synthase,
pubmed-meshheading:10464131-Nitric Oxide Synthase Type II,
pubmed-meshheading:10464131-RNA, Messenger,
pubmed-meshheading:10464131-Rats,
pubmed-meshheading:10464131-Rats, Wistar,
pubmed-meshheading:10464131-Spleen
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pubmed:year |
1999
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pubmed:articleTitle |
Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.
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pubmed:affiliation |
Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada. wallacej@ucalgary.ca
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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