| pubmed-article:10463434 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C0038838 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10463434 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10463434 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10463434 | pubmed:dateCreated | 1999-9-30 | lld:pubmed |
| pubmed-article:10463434 | pubmed:abstractText | High concentration of acetylcholine (ACh) caused a rapid and long lasting relaxation response in age-matched controls, whereas this response was significantly weaker in streptozotocin (STZ)-diabetic and cholesterol fed mice. The levels of basal and ACh-stimulated cyclic GMP in the aorta was also significantly smaller in STZ-diabetic and cholesterol-fed mice. The attenuated relaxation responses to ACh in both STZ-diabetic and cholesterol-fed mice were ameliorated by the chronic administration of cholestyramine. A prior incubation of aortic strips with superoxide dismutase (SOD, 60 U/ml) improved the recovery phase of the relaxation of diabetic aorta after single administration of ACh, whereas SOD had no effects on ACh-induced relaxation of aortic strips from cholesterol fed mice. These results suggest that superoxide anion may be responsible for an impairment of endothelium-dependent relaxation of aorta from STZ induced diabetic mice. It is further suggested that impairment of endothelium-dependent relaxation in STZ-diabetic and cholesterol fed mice may be caused by different mechanisms. | lld:pubmed |
| pubmed-article:10463434 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10463434 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463434 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10463434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10463434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10463434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463434 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10463434 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10463434 | pubmed:issn | 0916-8737 | lld:pubmed |
| pubmed-article:10463434 | pubmed:author | pubmed-author:SugiuraMM | lld:pubmed |
| pubmed-article:10463434 | pubmed:author | pubmed-author:KamataKK | lld:pubmed |
| pubmed-article:10463434 | pubmed:author | pubmed-author:NakajimaMM | lld:pubmed |
| pubmed-article:10463434 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10463434 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:10463434 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10463434 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10463434 | pubmed:pagination | 33-46 | lld:pubmed |
| pubmed-article:10463434 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10463434 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10463434 | pubmed:articleTitle | Effects of superoxide dismutase on the acetylcholine-induced relaxation response in cholesterol-fed and streptozotocin-induced diabetic mice. | lld:pubmed |
| pubmed-article:10463434 | pubmed:affiliation | Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan. kamata@hoshi.ac.jp | lld:pubmed |
| pubmed-article:10463434 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10463434 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:10463434 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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