|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1999-9-30
|
|
pubmed:abstractText |
High concentration of acetylcholine (ACh) caused a rapid and long lasting relaxation response in age-matched controls, whereas this response was significantly weaker in streptozotocin (STZ)-diabetic and cholesterol fed mice. The levels of basal and ACh-stimulated cyclic GMP in the aorta was also significantly smaller in STZ-diabetic and cholesterol-fed mice. The attenuated relaxation responses to ACh in both STZ-diabetic and cholesterol-fed mice were ameliorated by the chronic administration of cholestyramine. A prior incubation of aortic strips with superoxide dismutase (SOD, 60 U/ml) improved the recovery phase of the relaxation of diabetic aorta after single administration of ACh, whereas SOD had no effects on ACh-induced relaxation of aortic strips from cholesterol fed mice. These results suggest that superoxide anion may be responsible for an impairment of endothelium-dependent relaxation of aorta from STZ induced diabetic mice. It is further suggested that impairment of endothelium-dependent relaxation in STZ-diabetic and cholesterol fed mice may be caused by different mechanisms.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0916-8737
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
33-46
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10463434-Acetylcholine,
pubmed-meshheading:10463434-Analysis of Variance,
pubmed-meshheading:10463434-Animals,
pubmed-meshheading:10463434-Anticholesteremic Agents,
pubmed-meshheading:10463434-Aorta,
pubmed-meshheading:10463434-Blood Glucose,
pubmed-meshheading:10463434-Cholesterol,
pubmed-meshheading:10463434-Cholestyramine Resin,
pubmed-meshheading:10463434-Cyclic GMP,
pubmed-meshheading:10463434-Diabetes Mellitus, Experimental,
pubmed-meshheading:10463434-Male,
pubmed-meshheading:10463434-Mice,
pubmed-meshheading:10463434-Mice, Inbred ICR,
pubmed-meshheading:10463434-Muscle, Smooth, Vascular,
pubmed-meshheading:10463434-Muscle Relaxation,
pubmed-meshheading:10463434-Nitric Oxide,
pubmed-meshheading:10463434-Radioimmunoassay,
pubmed-meshheading:10463434-Streptozocin,
pubmed-meshheading:10463434-Superoxide Dismutase
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Effects of superoxide dismutase on the acetylcholine-induced relaxation response in cholesterol-fed and streptozotocin-induced diabetic mice.
|
|
pubmed:affiliation |
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan. kamata@hoshi.ac.jp
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
