Source:http://linkedlifedata.com/resource/pubmed/id/10462639
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
1999-11-10
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| pubmed:abstractText |
An analysis of hospital-acquired bacteraemia among ICU patients was carried out over a two-year period in order to determine the incidence, associated mortality rate and susceptibility pattern of causative pathogens. There was a high incidence of bacteraemia, occurring in 127 (18.4%) of 692 patients. Mortality attributable to nosocomial bacteraemia was 52% of the total 79 deaths from all causes. The highest mortality rate (58.5%) occurred in patients with fungal infections, whilst death from Gram-negative bacteraemia was only 17%. Over 98% of patients had underlying disease. Nearly half (46.8%) of 267 organisms isolated were Gram-positive. In comparison, Gram-negative bacteria accounted for 36.6% and the rest (17.6%) were fungi (mainly Candida albicans). The majority of the bactereamic episodes were monomicrobial (90.2%). Coagulase-negative staphylococci (CNS) were the commonest pathogens isolated, representing 32.6% of all organisms. Inducible beta-lactamase producing organism (Enterobacter spp. 9.7%, Serratia marcescens 6.7%, Klebsiella pneumoniae 6% and Pseudomonas aeruginosa 6%) formed the bulk of Gram-negative bacteria. In contrast, Escherichia coli (7.5%) and K. pneumoniae (4%) were the commonest Gram-negative bacteria from hospital-acquired bacteraemia in the general hospital population. The majority (80%) of CNS were resistant to methicillin (MRSE) but susceptible to vancomycin; they were relatively resistant to erythromycin, clindamycin and beta-lactams antibiotics. Whilst Gram-negative organisms were relatively susceptible to imipenem (85%), ciprofloxacin (88%) and amikacin (87%), they had unacceptably low levels of susceptibility to cefuroxime (59.3%), cefotaxime (71%), ceftazidime (60.9%), and piperacillin (51.1%). This study shows that hospital-acquired bacteraemia in ICU patients carries a poor prognosis. Information regarding the infective agents and their susceptibility in the ICU setting is valuable for the selection of empirical therapy before culture and susceptibility results are known.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0195-6701
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 The Hospital Infection Society.
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| pubmed:issnType |
Print
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| pubmed:volume |
43
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
49-56
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10462639-Adolescent,
pubmed-meshheading:10462639-Adult,
pubmed-meshheading:10462639-Aged,
pubmed-meshheading:10462639-Aged, 80 and over,
pubmed-meshheading:10462639-Anti-Bacterial Agents,
pubmed-meshheading:10462639-Bacteremia,
pubmed-meshheading:10462639-Bacteria,
pubmed-meshheading:10462639-Candida,
pubmed-meshheading:10462639-Child,
pubmed-meshheading:10462639-Child, Preschool,
pubmed-meshheading:10462639-Cross Infection,
pubmed-meshheading:10462639-Female,
pubmed-meshheading:10462639-Fungemia,
pubmed-meshheading:10462639-Humans,
pubmed-meshheading:10462639-Incidence,
pubmed-meshheading:10462639-Infant,
pubmed-meshheading:10462639-Intensive Care Units,
pubmed-meshheading:10462639-Kuwait,
pubmed-meshheading:10462639-Male,
pubmed-meshheading:10462639-Microbial Sensitivity Tests,
pubmed-meshheading:10462639-Middle Aged,
pubmed-meshheading:10462639-Prevalence
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| pubmed:year |
1999
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| pubmed:articleTitle |
An analysis of hospital-acquired bacteraemia in intensive care unit patients in a university hospital in Kuwait.
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| pubmed:affiliation |
Department of Microbiology, Department of Anesthesiology, Mubarak Al-Kabeer Hospital and Faculty of Medicine, P. O. Box 24923, Safat, 13110, Kuwait.
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| pubmed:publicationType |
Journal Article
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