Source:http://linkedlifedata.com/resource/pubmed/id/10462385
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
1999-9-16
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| pubmed:abstractText |
It has been suggested that hepatitis C virus (HCV) infection could be associated with B-cell clonal expansion. The aim of this study was to analyze the relationship between lymphoproliferative disorders and HCV infection in liver transplant recipients. We studied 157 patients receiving a liver transplant between January 1989 and May 1997 with a follow-up longer than 3 months. The incidence of posttransplant lymphoproliferative disorders (PTLDs) was analyzed with reference to the indication for liver transplantation, the induction and maintenance immunosuppression, the incidence of acute rejection episodes, and Epstein-Barr virus (EBV) infection. Six PTLDs occurred after a median posttransplant follow-up of 7 months (3.8%). Four of the 6 PTLDs occurred among the 38 patients transplanted for HCV-related cirrhosis, and 2 PTLDs occurred in the 119 patients receiving a liver transplant for non-HCV liver diseases (10.5% vs. 1.7%, respectively; P =.03). The 4-year probability of PTLD was significantly higher in patients receiving a liver transplant for HCV-related cirrhosis than non-HCV liver diseases (12.3% vs. 2.2%, respectively; P =.015). Patients receiving a liver transplant for HCV-related cirrhosis were more likely to receive antithymocyte globulins (ATG). However, in patients treated with ATG, the 4-year probability of PTLD was higher among those patients receiving a liver transplant for HCV-related cirrhosis than for non-HCV liver diseases (27.1% vs. 6.4%, respectively; P =.08). EBV gene products were detected in tumor tissues in 3 of 4 patients with HCV-associated PTLD. Our data suggest that, in addition to EBV infection, 2 mutually nonexclusive factors, i.e., the use of ATG and HCV infection, could play a role in the occurrence of PTLD after a liver transplant for HCV-related cirrhosis.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0270-9139
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
775-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10462385-Adult,
pubmed-meshheading:10462385-Aged,
pubmed-meshheading:10462385-B-Lymphocytes,
pubmed-meshheading:10462385-Female,
pubmed-meshheading:10462385-Hepatitis C,
pubmed-meshheading:10462385-Herpesvirus 4, Human,
pubmed-meshheading:10462385-Humans,
pubmed-meshheading:10462385-Liver Transplantation,
pubmed-meshheading:10462385-Lymphocyte Activation,
pubmed-meshheading:10462385-Lymphoproliferative Disorders,
pubmed-meshheading:10462385-Male,
pubmed-meshheading:10462385-Middle Aged
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| pubmed:year |
1999
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| pubmed:articleTitle |
Role of hepatitis C virus in lymphoproliferative disorders after liver transplantation.
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| pubmed:affiliation |
Departments of Hepatology-Gastroenterology, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
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| pubmed:publicationType |
Journal Article
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