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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-10-12
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pubmed:abstractText |
We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged. This stabilizing effect of depolarization is mediated through the 3' untranslated region of a long form of the alpha1B mRNA and may represent a form of modulation of N-channel levels that does not require changes in gene transcription. Increases in N channel expression would affect several key neuronal functions controlled by calcium, including transmitter release and neurite outgrowth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, L-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nimodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
785-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10461216-3' Untranslated Regions,
pubmed-meshheading:10461216-Action Potentials,
pubmed-meshheading:10461216-Animals,
pubmed-meshheading:10461216-Calcium Channel Blockers,
pubmed-meshheading:10461216-Calcium Channels,
pubmed-meshheading:10461216-Calcium Channels, L-Type,
pubmed-meshheading:10461216-Cells, Cultured,
pubmed-meshheading:10461216-Gene Expression Regulation,
pubmed-meshheading:10461216-Membrane Potentials,
pubmed-meshheading:10461216-Nerve Growth Factors,
pubmed-meshheading:10461216-Neurons,
pubmed-meshheading:10461216-Nimodipine,
pubmed-meshheading:10461216-Peptides,
pubmed-meshheading:10461216-RNA, Messenger,
pubmed-meshheading:10461216-Rats,
pubmed-meshheading:10461216-Superior Cervical Ganglion,
pubmed-meshheading:10461216-Transcription, Genetic,
pubmed-meshheading:10461216-omega-Conotoxin GVIA
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pubmed:year |
1999
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pubmed:articleTitle |
Calcium channel activation stabilizes a neuronal calcium channel mRNA.
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pubmed:affiliation |
Department of Neuroscience, 192 Thayer Street, Brown University, Box 1953, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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