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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-9-28
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pubmed:abstractText |
We compared the effects of single doses of etomidate and thiopentone on adrenocortical function in a randomised controlled clinical trial involving 35 critically ill patients who needed a general anaesthetic. Just before induction of anaesthesia, a baseline blood cortisol sample was taken. Twenty-four hours later we performed a short adrenocorticotrophic hormone stimulation test. No patient had a low cortisol level (< 160 nmol.l-1) at any time during the study. Baseline, pre-ACTH and post-ACTH cortisol levels were similar in the two groups. However, significantly more patients in the etomidate group had an ACTH-stimulated cortisol increment < 200 nmol.l-1. The clinical significance of these findings is not clear, but we conclude that single doses of etomidate may interfere with cortisol synthesis for at least 24 h in the critically ill.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-2409
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
861-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10460557-Adolescent,
pubmed-meshheading:10460557-Adrenal Cortex,
pubmed-meshheading:10460557-Adrenal Cortex Function Tests,
pubmed-meshheading:10460557-Adrenocorticotropic Hormone,
pubmed-meshheading:10460557-Adult,
pubmed-meshheading:10460557-Aged,
pubmed-meshheading:10460557-Aged, 80 and over,
pubmed-meshheading:10460557-Anesthesia, General,
pubmed-meshheading:10460557-Anesthetics, Intravenous,
pubmed-meshheading:10460557-Critical Illness,
pubmed-meshheading:10460557-Etomidate,
pubmed-meshheading:10460557-Female,
pubmed-meshheading:10460557-Hospital Mortality,
pubmed-meshheading:10460557-Humans,
pubmed-meshheading:10460557-Hydrocortisone,
pubmed-meshheading:10460557-Intensive Care,
pubmed-meshheading:10460557-Male,
pubmed-meshheading:10460557-Middle Aged,
pubmed-meshheading:10460557-Thiopental
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pubmed:year |
1999
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pubmed:articleTitle |
Adrenocortical function in critically ill patients 24 h after a single dose of etomidate.
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pubmed:affiliation |
Department of Anaesthesia, Ipswwich Hospital, Ipswich 1p1 5 PD, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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