Linked Life Data

10459554

Source:http://linkedlifedata.com/resource/pubmed/id/10459554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-9-7
pubmed:abstractText
Animal models using rabbits were developed to accumulate a variable body fat mass (FM) in two groups of animals while the fat-free mass (FFM), eg, total body protein, was maintained essentially similar between the groups. Thiobarbituric acid-reactive substances (TBARS) were measured as an index of lipid peroxidation and were found to be higher in the whole-body tissues of animals with a higher FM. Bacterial toxin (lipopolysaccharide [LPS]) also induced higher lipid peroxidation in animals with a higher FM, with a concomitant incidence of bloody mucous diarrhea. To our knowledge, this is the first evidence to show the effect of body FM to aggravate toxin-induced infections leading to diarrhea. The overall results suggest further investigations to explore the possible role of body fat in infectious diseases in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
946-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Higher body fat aggravates toxin-induced infectious episodes.
pubmed:affiliation
National Institute for Cholera and Enteric Diseases, Calcutta, India.
pubmed:publicationType
Journal Article