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rdf:type |
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lifeskim:mentions |
umls-concept:C0005479,
umls-concept:C0006711,
umls-concept:C0021107,
umls-concept:C0026162,
umls-concept:C0030608,
umls-concept:C0086466,
umls-concept:C0262950,
umls-concept:C0441655,
umls-concept:C0686907,
umls-concept:C1272883,
umls-concept:C1272936,
umls-concept:C1280500,
umls-concept:C1523935,
umls-concept:C1533685,
umls-concept:C1555721,
umls-concept:C1706204
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pubmed:issue |
2 Suppl
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pubmed:dateCreated |
1999-9-27
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pubmed:abstractText |
This in vivo study investigated the influence of two calcium phosphate particle sizes (40-80 microm and 200-500 microm) on the cellular degradation activity associated with the bone substitution process of two injectable bone substitutes (IBS). The tested biomaterials were obtained by associating a biphasic calcium phosphate (BCP) ceramic mineral phase and a 3% aqueous solution of a cellulosic polymer (hydroxypropylmethylcellulose). Both were injected into osseous defects at the distal end of rabbit femurs for 2- and 3-week periods. Quantitative results for tartrate-resistant acid phosphatase (TRAP) cellular activity, new bone formation, and ceramic resorption were studied for statistical purposes. Positive TRAP-stained degradation cells were significantly more numerous for IBS 40-80 than IBS 200-500, regardless of implantation time. BCP degradation was quite marked during the first 2 weeks for IBS 40-80, and bone colonization occurred more extensively for IBS 40-80 than for IBS 200-500. The resorption-bone substitution process occurred earlier and faster for IBS 40-80 than IBS 200-500. Both tested IBS displayed similar biological efficiency, with conserved in vivo bioactivity and bone-filling ability. Differences in calcium phosphate particle sizes influenced cellular degradation activity and ceramic resorption but were compatible with efficient bone substitution.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lactose,
http://linkedlifedata.com/resource/pubmed/chemical/MK 458,
http://linkedlifedata.com/resource/pubmed/chemical/Methylcellulose,
http://linkedlifedata.com/resource/pubmed/chemical/Minerals,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazines,
http://linkedlifedata.com/resource/pubmed/chemical/beta-tricalcium...,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
8756-3282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71S-74S
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10458280-Acid Phosphatase,
pubmed-meshheading:10458280-Animals,
pubmed-meshheading:10458280-Biocompatible Materials,
pubmed-meshheading:10458280-Biodegradation, Environmental,
pubmed-meshheading:10458280-Bone Substitutes,
pubmed-meshheading:10458280-Calcium Phosphates,
pubmed-meshheading:10458280-Electron Probe Microanalysis,
pubmed-meshheading:10458280-Female,
pubmed-meshheading:10458280-Femur,
pubmed-meshheading:10458280-Implants, Experimental,
pubmed-meshheading:10458280-Injections,
pubmed-meshheading:10458280-Isoenzymes,
pubmed-meshheading:10458280-Lactose,
pubmed-meshheading:10458280-Materials Testing,
pubmed-meshheading:10458280-Methylcellulose,
pubmed-meshheading:10458280-Microscopy, Electron, Scanning,
pubmed-meshheading:10458280-Minerals,
pubmed-meshheading:10458280-Osseointegration,
pubmed-meshheading:10458280-Oxazines,
pubmed-meshheading:10458280-Particle Size,
pubmed-meshheading:10458280-Rabbits
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pubmed:year |
1999
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pubmed:articleTitle |
Short-term effects of mineral particle sizes on cellular degradation activity after implantation of injectable calcium phosphate biomaterials and the consequences for bone substitution.
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pubmed:affiliation |
Equipe INSERM Matériaux d'intérêt Biologique, Faculté de Chirurgie Dentaire, Nantes, France. gauthier@vet-nantes.fr
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pubmed:publicationType |
Journal Article
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