Source:http://linkedlifedata.com/resource/pubmed/id/10455213
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1999-9-13
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pubmed:abstractText |
The Tall cell variant of papillary carcinoma of the thyroid (TCV) is characterized by the proliferation of oxyphilic, tall, columnar cells with a height-to-width ratio of at least 2:1. TCV exhibits more aggressive clinical behavior than conventional thyroid papillary carcinoma (CPC). Cytologic features suggestive of TCV have been described in fine-needle aspiration material from primary tumors. Similarly, loss of heterozygosity (LOH) for chromosome 1 (D1S243) and the p53 gene (TP53) have been reported in TCV but not in CPC, thus making exploitation of this genetic feature a potential tool for molecular discrimination between these two neoplasms.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1999 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238-42
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pubmed:dateRevised |
2010-1-15
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pubmed:meshHeading |
pubmed-meshheading:10455213-Adult,
pubmed-meshheading:10455213-Aged,
pubmed-meshheading:10455213-Aged, 80 and over,
pubmed-meshheading:10455213-Carcinoma, Papillary,
pubmed-meshheading:10455213-Chromosomes, Human, Pair 1,
pubmed-meshheading:10455213-DNA, Neoplasm,
pubmed-meshheading:10455213-DNA Mutational Analysis,
pubmed-meshheading:10455213-Female,
pubmed-meshheading:10455213-Humans,
pubmed-meshheading:10455213-Loss of Heterozygosity,
pubmed-meshheading:10455213-Male,
pubmed-meshheading:10455213-Middle Aged,
pubmed-meshheading:10455213-Neoplasm Recurrence, Local,
pubmed-meshheading:10455213-Polymerase Chain Reaction,
pubmed-meshheading:10455213-Thyroid Neoplasms,
pubmed-meshheading:10455213-Tumor Suppressor Protein p53
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pubmed:year |
1999
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pubmed:articleTitle |
The Tall cell variant of papillary carcinoma of the thyroid: cytologic features and loss of heterozygosity of metastatic and/or recurrent neoplasms and primary neoplasms.
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pubmed:affiliation |
Cytopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article
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