Source:http://linkedlifedata.com/resource/pubmed/id/10453025
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1999-9-14
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pubmed:abstractText |
Mice deficient in lymphotoxin (LT)-alpha lack peripheral lymph nodes and Peyer's patches and have profound defects in development of follicular dendritic cell networks, germinal center formation, and T/B cell segregation in the spleen. Although LTalpha is known to be expressed by NK cells as well as T and B lymphocytes, the requirement of LTalpha for NK cell functions is largely unknown. To address this issue, we have assessed NK cell functions in LTalpha-deficient mice by evaluating tumor models with known requirements for NK cells to control their growth and metastasis. Syngeneic B16F10 melanoma cells inoculated s.c. grew more rapidly in LTalpha-/- mice than in the wild-type littermates, and the formation of experimental pulmonary metastases was significantly enhanced in LTalpha-/- mice. Although LTalpha-/- mice exhibited almost a normal total number of NK cells in spleen, they showed an impaired recruitment of NK cells to lung and liver. Additionally, lytic NK cells were not efficiently produced from LTalpha-/- bone marrow cells in vitro in the presence of IL-2 and IL-15. These data suggest that LTalpha signaling may be involved in the maturation and recruitment of NK cells and may play an important role in antitumor surveillance.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2809-15
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10453025-Animals,
pubmed-meshheading:10453025-Bone Marrow Cells,
pubmed-meshheading:10453025-Carcinoma, Lewis Lung,
pubmed-meshheading:10453025-Cell Division,
pubmed-meshheading:10453025-Cell Movement,
pubmed-meshheading:10453025-Cytotoxicity, Immunologic,
pubmed-meshheading:10453025-Hematopoietic Stem Cells,
pubmed-meshheading:10453025-Immunologic Deficiency Syndromes,
pubmed-meshheading:10453025-Killer Cells, Natural,
pubmed-meshheading:10453025-Lung Neoplasms,
pubmed-meshheading:10453025-Lymphocyte Activation,
pubmed-meshheading:10453025-Lymphotoxin-alpha,
pubmed-meshheading:10453025-Melanoma, Experimental,
pubmed-meshheading:10453025-Mice,
pubmed-meshheading:10453025-Mice, Inbred C57BL,
pubmed-meshheading:10453025-Mice, Knockout,
pubmed-meshheading:10453025-Mutagenesis, Site-Directed,
pubmed-meshheading:10453025-Organ Specificity,
pubmed-meshheading:10453025-Spleen
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pubmed:year |
1999
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pubmed:articleTitle |
Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment.
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pubmed:affiliation |
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp.-Frederick, National Cancer Institute-Frederic Cancer Research and Development Center, MD 21702, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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