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pubmed-article:10450967pubmed:abstractTextCarbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).lld:pubmed
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pubmed-article:10450967pubmed:articleTitleThe design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.lld:pubmed
pubmed-article:10450967pubmed:affiliationAgrEvo UK Limited, Essex, England. stephen.lindell@agrevo.comlld:pubmed
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