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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1999-9-24
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pubmed:abstractText |
Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP Deaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Coformycin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Formycins,
http://linkedlifedata.com/resource/pubmed/chemical/Herbicides,
http://linkedlifedata.com/resource/pubmed/chemical/Purine Nucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/aristeromycin,
http://linkedlifedata.com/resource/pubmed/chemical/nebularine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1985-90
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:10450967-AMP Deaminase,
pubmed-meshheading:10450967-Adenosine,
pubmed-meshheading:10450967-Adenosine Triphosphate,
pubmed-meshheading:10450967-Coformycin,
pubmed-meshheading:10450967-Drug Design,
pubmed-meshheading:10450967-Drug Evaluation, Preclinical,
pubmed-meshheading:10450967-Enzyme Inhibitors,
pubmed-meshheading:10450967-Formycins,
pubmed-meshheading:10450967-Herbicides,
pubmed-meshheading:10450967-Inhibitory Concentration 50,
pubmed-meshheading:10450967-Phosphorylation,
pubmed-meshheading:10450967-Purine Nucleosides,
pubmed-meshheading:10450967-Ribonucleosides,
pubmed-meshheading:10450967-Structure-Activity Relationship
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pubmed:year |
1999
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pubmed:articleTitle |
The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
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pubmed:affiliation |
AgrEvo UK Limited, Essex, England. stephen.lindell@agrevo.com
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pubmed:publicationType |
Journal Article
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