Source:http://linkedlifedata.com/resource/pubmed/id/10450955
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
1999-9-24
|
| pubmed:abstractText |
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1927-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10450955-Acetolactate Synthase,
pubmed-meshheading:10450955-Computer Simulation,
pubmed-meshheading:10450955-Computer-Aided Design,
pubmed-meshheading:10450955-Drug Design,
pubmed-meshheading:10450955-Enzyme Inhibitors,
pubmed-meshheading:10450955-Inhibitory Concentration 50,
pubmed-meshheading:10450955-Models, Molecular
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
The design and synthesis of ALS inhibitors from pharmacophore models.
|
| pubmed:affiliation |
Elemento-Organic Chemistry Institute, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|