10450949

Source:http://linkedlifedata.com/resource/pubmed/id/10450949

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013171, umls-concept:C0205250, umls-concept:C0243192, umls-concept:C0597357, umls-concept:C0908873, umls-concept:C1880355
pubmed:issue	14
pubmed:dateCreated	1999-9-24
pubmed:abstractText	Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (Ki = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY-132983.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Bridged Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Carbachol, http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M1, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic, http://linkedlifedata.com/resource/pubmed/chemical/Thiadiazoles, http://linkedlifedata.com/resource/pubmed/chemical/xanomeline
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0960-894X
pubmed:author	pubmed-author:Abou-GharbiaMM, pubmed-author:BoastC ACA, pubmed-author:HusbandsG MGM, pubmed-author:MoyerJ AJA, pubmed-author:RothR HRHJr, pubmed-author:SteinR PRP, pubmed-author:TasseR PRP, pubmed-author:TokolicsJJ
pubmed:issnType	Print
pubmed:day	19
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1895-900
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:10450949-Administration, Oral, pubmed-meshheading:10450949-Animals, pubmed-meshheading:10450949-Bridged Compounds, pubmed-meshheading:10450949-CHO Cells, pubmed-meshheading:10450949-Carbachol, pubmed-meshheading:10450949-Cerebral Cortex, pubmed-meshheading:10450949-Cognition Disorders, pubmed-meshheading:10450949-Computer Simulation, pubmed-meshheading:10450949-Cricetinae, pubmed-meshheading:10450949-Crystallography, X-Ray, pubmed-meshheading:10450949-Drug Design, pubmed-meshheading:10450949-Drug Evaluation, Preclinical, pubmed-meshheading:10450949-Humans, pubmed-meshheading:10450949-Macaca mulatta, pubmed-meshheading:10450949-Maze Learning, pubmed-meshheading:10450949-Models, Molecular, pubmed-meshheading:10450949-Muscarinic Agonists, pubmed-meshheading:10450949-Phosphatidylinositols, pubmed-meshheading:10450949-Protein Conformation, pubmed-meshheading:10450949-Pyrazines, pubmed-meshheading:10450949-Pyridines, pubmed-meshheading:10450949-Rats, pubmed-meshheading:10450949-Receptor, Muscarinic M1, pubmed-meshheading:10450949-Receptors, Muscarinic, pubmed-meshheading:10450949-Salivation, pubmed-meshheading:10450949-Structure-Activity Relationship, pubmed-meshheading:10450949-Thiadiazoles
pubmed:year	1999
pubmed:articleTitle	Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling.
pubmed:affiliation	Wyeth-Ayerst Research, Princeton, NJ 08543-8000, USA.
pubmed:publicationType	Journal Article