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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1999-9-2
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pubmed:abstractText |
Nucleotide variants in several genes for lipid and methionine metabolism influence the risk of premature atherosclerosis. Ten percent of single nucleotide substitutions in these genes involve mRNA splice sites. The effects of some of these changes on splicing and on phenotypic severity are not inherently obvious.
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pubmed:grant |
|
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10449689-Amino Acid Substitution,
pubmed-meshheading:10449689-Arteriosclerosis,
pubmed-meshheading:10449689-DNA Mutational Analysis,
pubmed-meshheading:10449689-Gene Expression Regulation,
pubmed-meshheading:10449689-Genes,
pubmed-meshheading:10449689-Genetic Predisposition to Disease,
pubmed-meshheading:10449689-Humans,
pubmed-meshheading:10449689-Hyperlipidemias,
pubmed-meshheading:10449689-Information Theory,
pubmed-meshheading:10449689-Lipid Metabolism,
pubmed-meshheading:10449689-Methionine,
pubmed-meshheading:10449689-Models, Genetic,
pubmed-meshheading:10449689-Phenotype,
pubmed-meshheading:10449689-Point Mutation,
pubmed-meshheading:10449689-Protein Biosynthesis,
pubmed-meshheading:10449689-RNA, Messenger,
pubmed-meshheading:10449689-RNA Splicing,
pubmed-meshheading:10449689-Risk Factors,
pubmed-meshheading:10449689-Severity of Illness Index
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pubmed:year |
1999
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pubmed:articleTitle |
Splice-site mutations in atherosclerosis candidate genes: relating individual information to phenotype.
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pubmed:affiliation |
Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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