| pubmed-article:10449474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C0033607 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C1335528 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10449474 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:10449474 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10449474 | pubmed:dateCreated | 1999-9-2 | lld:pubmed |
| pubmed-article:10449474 | pubmed:abstractText | In order to analyze the impact of protease gene polymorphism on response to regimens containing a protease inhibitor, the entire protease coding domain from 58 human immunodeficiency virus type 1 (HIV-1)-infected patients who were protease inhibitor naive was sequenced before therapy was started. Plasma HIV-1 RNA levels were measured at baseline and at month 3 and month 6 after treatment. All patients were treated with a combination of two reverse transcriptase inhibitors and a protease inhibitor (saquinavir EOF [n = 28], ritonavir [n = 16], or indinavir [n = 14]). Before treatment, 30 different positions whose codons differed from the subtype B consensus sequence were observed. Major mutations associated with protease inhibitor resistance were not observed. No statistical correlation between the number of amino acid differences and the treatment efficacy at month 3 (-2.4 log) or month 6 (-2.7 log) was observed. At baseline, genotypic analysis of the HIV-1 protease gene of patients who have never received a protease inhibitor does not allow prediction of the efficacy of regimens containing a protease inhibitor. | lld:pubmed |
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| pubmed-article:10449474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10449474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10449474 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10449474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10449474 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10449474 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:BricaireFF | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:HurauxJ MJM | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:BossiPP | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:KatlamaCC | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:AgutHH | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:MourouxMM | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:CalvezVV | lld:pubmed |
| pubmed-article:10449474 | pubmed:author | pubmed-author:YvonAA | lld:pubmed |
| pubmed-article:10449474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10449474 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:10449474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10449474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10449474 | pubmed:pagination | 2910-2 | lld:pubmed |
| pubmed-article:10449474 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10449474 | pubmed:meshHeading | pubmed-meshheading:10449474... | lld:pubmed |
| pubmed-article:10449474 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10449474 | pubmed:articleTitle | Polymorphism of the human immunodeficiency virus type 1 (HIV-1) protease gene and response of HIV-1-infected patients to a protease inhibitor. | lld:pubmed |
| pubmed-article:10449474 | pubmed:affiliation | Department of Virology, Pitié-Salpêtrière Hospital, Paris, France. | lld:pubmed |
| pubmed-article:10449474 | pubmed:publicationType | Journal Article | lld:pubmed |
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