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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-9-2
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pubmed:abstractText |
In order to analyze the impact of protease gene polymorphism on response to regimens containing a protease inhibitor, the entire protease coding domain from 58 human immunodeficiency virus type 1 (HIV-1)-infected patients who were protease inhibitor naive was sequenced before therapy was started. Plasma HIV-1 RNA levels were measured at baseline and at month 3 and month 6 after treatment. All patients were treated with a combination of two reverse transcriptase inhibitors and a protease inhibitor (saquinavir EOF [n = 28], ritonavir [n = 16], or indinavir [n = 14]). Before treatment, 30 different positions whose codons differed from the subtype B consensus sequence were observed. Major mutations associated with protease inhibitor resistance were not observed. No statistical correlation between the number of amino acid differences and the treatment efficacy at month 3 (-2.4 log) or month 6 (-2.7 log) was observed. At baseline, genotypic analysis of the HIV-1 protease gene of patients who have never received a protease inhibitor does not allow prediction of the efficacy of regimens containing a protease inhibitor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7486905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7576926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7626598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7700387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7815532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-7831807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8107264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8202533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8356053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8627733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8648209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8673921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8834868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8853733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8913459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-8970946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-9543442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-9562584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-9754946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449474-9764779
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2910-2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1999
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pubmed:articleTitle |
Polymorphism of the human immunodeficiency virus type 1 (HIV-1) protease gene and response of HIV-1-infected patients to a protease inhibitor.
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pubmed:affiliation |
Department of Virology, Pitié-Salpêtrière Hospital, Paris, France.
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pubmed:publicationType |
Journal Article
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