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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-8-24
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pubmed:abstractText |
Epidemiological and dietary studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer, possibly through a mechanism involving inhibition of cyclooxygenase (COX)-2, which is overexpressed in premalignant adenomatous polyps and colon cancer. Because ultraviolet light (UV) can induce COX-2 and nonspecific NSAIDs can decrease UV-induced skin cancer, we evaluated the ability of two compounds, celecoxib (a specific COX-2 inhibitor) and indomethacin (a nonspecific NSAID), to block UV-induced skin tumor development in SKH:HR-1-hrBr hairless mice. Mice fed 150 or 500 ppm celecoxib showed a dose-dependent reduction (60% and 89%, respectively) in tumor yield. Indomethacin (4ppm) reduced tumor yield by 78%. Although both acute and chronic UV exposure increased cell proliferation and edema, neither compound reduced these parameters. In contrast, UV-induced prostaglandin synthesis in the epidermis was effectively blocked by both compounds. UV-induced increases in COX-2 expression in skin were also not altered in any of the treatment groups. Similarly, tumors that constitutively express high levels of COX-2 displayed no reduction by treatment with celecoxib or indomethacin. The dramatic protective effects of celecoxib suggests that specific COX-2 inhibitors may offer a way to safely reduce the risk of skin cancer in humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0899-1987
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10449029-Animals,
pubmed-meshheading:10449029-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:10449029-Body Weight,
pubmed-meshheading:10449029-Cell Division,
pubmed-meshheading:10449029-Cyclooxygenase 2,
pubmed-meshheading:10449029-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:10449029-Cyclooxygenase Inhibitors,
pubmed-meshheading:10449029-Dinoprostone,
pubmed-meshheading:10449029-Dose-Response Relationship, Radiation,
pubmed-meshheading:10449029-Feeding Behavior,
pubmed-meshheading:10449029-Indomethacin,
pubmed-meshheading:10449029-Isoenzymes,
pubmed-meshheading:10449029-Mice,
pubmed-meshheading:10449029-Mice, Hairless,
pubmed-meshheading:10449029-Neoplasms, Radiation-Induced,
pubmed-meshheading:10449029-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10449029-Pyrazoles,
pubmed-meshheading:10449029-Skin Neoplasms,
pubmed-meshheading:10449029-Sulfonamides,
pubmed-meshheading:10449029-Ultraviolet Rays
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pubmed:year |
1999
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pubmed:articleTitle |
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
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pubmed:affiliation |
The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville 78957, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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