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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-8-19
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pubmed:abstractText |
The nucleus of the solitary tract (NTS) is a primary site at which vagal afferents terminate. Because afferent vagal nerve stimulation has been demonstrated to have anticonvulsant effects, it is likely that changes in synaptic transmission in the NTS can regulate seizure susceptibility. We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1051-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10448815-Animals,
pubmed-meshheading:10448815-Bicuculline,
pubmed-meshheading:10448815-Electric Stimulation Therapy,
pubmed-meshheading:10448815-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10448815-GABA Agonists,
pubmed-meshheading:10448815-Glutamates,
pubmed-meshheading:10448815-Humans,
pubmed-meshheading:10448815-Kynurenic Acid,
pubmed-meshheading:10448815-Lidocaine,
pubmed-meshheading:10448815-Limbic System,
pubmed-meshheading:10448815-Male,
pubmed-meshheading:10448815-Muscimol,
pubmed-meshheading:10448815-Pentylenetetrazole,
pubmed-meshheading:10448815-Rats,
pubmed-meshheading:10448815-Rats, Sprague-Dawley,
pubmed-meshheading:10448815-Seizures,
pubmed-meshheading:10448815-Solitary Nucleus,
pubmed-meshheading:10448815-Synaptic Transmission,
pubmed-meshheading:10448815-Vagus Nerve,
pubmed-meshheading:10448815-gamma-Aminobutyric Acid
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pubmed:year |
1999
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pubmed:articleTitle |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
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pubmed:affiliation |
Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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