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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-9-2
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pubmed:abstractText |
Neuronal differentiation and development of synaptic specializations are strongly influenced by cellular interactions. We compared the effects of interaction with distinct autonomic targets on the molecular and biophysical differentiation of 'upstream' neuron-neuron synapses. Contact with cardiac tissue induced expression of nicotinic receptor channels (nAChRs) distinct from those induced by renal tissue in presynaptic autonomic neurons. The kinetics of cholinergic currents at interneuronal synapses are dictated by the peripheral target contacted. Analysis of the nAChR channel subtypes and subunits in individual neurons demonstrated that the profile of transmitter receptors expressed at mature neuron-neuron synapses develops from the convergent influences of input-derived (anterograde) and target-specific (retrograde) signals.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/NS29071,
http://linkedlifedata.com/resource/pubmed/grant/NS35090,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-10,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-11,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-13,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-13S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-14,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-15,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-16,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS029071-17
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-1648605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-1652527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-1720573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-184272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-2642012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-3267226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-3357893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-3667699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-7678641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-7693387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-7778876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-7826633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-7876208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8125198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8335115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8501530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8598930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8613719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8663494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-8663984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-9097938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-9414162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-9491987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-9596789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10448217-9596790
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
528-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10448217-Animals,
pubmed-meshheading:10448217-Cell Communication,
pubmed-meshheading:10448217-Cells, Cultured,
pubmed-meshheading:10448217-Chick Embryo,
pubmed-meshheading:10448217-Electric Conductivity,
pubmed-meshheading:10448217-Heart,
pubmed-meshheading:10448217-Ion Channels,
pubmed-meshheading:10448217-Kidney,
pubmed-meshheading:10448217-Kinetics,
pubmed-meshheading:10448217-Neurons,
pubmed-meshheading:10448217-Receptors, Cholinergic,
pubmed-meshheading:10448217-Receptors, Nicotinic,
pubmed-meshheading:10448217-Sympathetic Nervous System,
pubmed-meshheading:10448217-Synapses
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pubmed:year |
1999
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pubmed:articleTitle |
Target-specific control of nicotinic receptor expression at developing interneuronal synapses in chick.
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pubmed:affiliation |
Columbia University, College of Physicians and Surgeons, Department of Anatomy and Cell Biology and The Center for Neurobiology and Behavior, 1051 Riverside Drive, New York, New York 10032, USA. pd11@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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