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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-9-17
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pubmed:abstractText |
Alterations in transcription factor activities in aged mice may lead to the production of many inflammatory molecules in the absence of exogenous stimulation. Splenocytes from 22-month-old female C57BL/6 mice are dysregulated in their capacity to control the inducible nitric oxide synthase gene as a result of elevations in the endogenous levels and activity of interferon (IFN)-gamma. Splenocytes from aged mice produced high levels of IFN-gamma in vitro and active STAT-1 was found in nuclear extracts from these splenocytes. Administration to aged mice of neutralizing antibodies against IFN-gamma imposed appropriate regulation over nitric oxide production by stimulated splenocytes. Reestablishment of normal redox balance following dietary supplementation of aged mice with activators of the peroxisome proliferator-activated receptor alpha or the antioxidant alpha-tocopherol (vitamin E) restored appropriate regulation over both the production of IFN-gamma and the secretion of nitric oxide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/pirinixic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-36
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10448012-Aging,
pubmed-meshheading:10448012-Animals,
pubmed-meshheading:10448012-Antibodies,
pubmed-meshheading:10448012-Cell Nucleus,
pubmed-meshheading:10448012-DNA-Binding Proteins,
pubmed-meshheading:10448012-Enzyme Induction,
pubmed-meshheading:10448012-Female,
pubmed-meshheading:10448012-Interferon-gamma,
pubmed-meshheading:10448012-Lipopolysaccharides,
pubmed-meshheading:10448012-Macrophages,
pubmed-meshheading:10448012-Mice,
pubmed-meshheading:10448012-Mice, Inbred C57BL,
pubmed-meshheading:10448012-Nitric Oxide,
pubmed-meshheading:10448012-Nitric Oxide Synthase,
pubmed-meshheading:10448012-Nitric Oxide Synthase Type II,
pubmed-meshheading:10448012-Oxidation-Reduction,
pubmed-meshheading:10448012-Pyrimidines,
pubmed-meshheading:10448012-RNA, Messenger,
pubmed-meshheading:10448012-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10448012-STAT1 Transcription Factor,
pubmed-meshheading:10448012-Spleen,
pubmed-meshheading:10448012-Trans-Activators,
pubmed-meshheading:10448012-Transcription Factors,
pubmed-meshheading:10448012-Vitamin E
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pubmed:year |
1999
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pubmed:articleTitle |
Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E.
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pubmed:affiliation |
Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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