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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0011065,
umls-concept:C0019704,
umls-concept:C0033684,
umls-concept:C0035647,
umls-concept:C0205369,
umls-concept:C0332281,
umls-concept:C0441655,
umls-concept:C0441889,
umls-concept:C1337615,
umls-concept:C1511636
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pubmed:issue |
2
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pubmed:dateCreated |
1999-9-14
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pubmed:abstractText |
The ability of cytotoxic T lymphocytes (CTL) to control and influence the outcome of human immunodeficiency virus (HIV) infection is not fully understood. The association between HIV-CTL activity and disease progression was evaluated prospectively in 36 HIV-1-infected individuals with a median follow-up of 3.0 years. HIV-CTL activity was measured in a 4 h Cr* release assay using autologous target cells expressing HIV-1 BRU isolate gene products (gp-120, gag, pol, nef) and a bulk culture of autologous effector cells. The CD4 count was measured at enrolment and plasma HIV RNA was measured retrospectively. The present study failed to support the hypothesis that HIV-CTL activity, as measured using the present method, is important in reducing the risk of death in HIV-infected individuals. However, using other approaches and methods could possibly yield other conclusions, and further prospective studies are needed to examine the relationship between CTL and disease progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, pol,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0300-9475
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10447929-Adult,
pubmed-meshheading:10447929-CD4 Lymphocyte Count,
pubmed-meshheading:10447929-Cells, Cultured,
pubmed-meshheading:10447929-Disease Progression,
pubmed-meshheading:10447929-Female,
pubmed-meshheading:10447929-Follow-Up Studies,
pubmed-meshheading:10447929-Gene Products, gag,
pubmed-meshheading:10447929-Gene Products, nef,
pubmed-meshheading:10447929-Gene Products, pol,
pubmed-meshheading:10447929-HIV Antigens,
pubmed-meshheading:10447929-HIV Envelope Protein gp120,
pubmed-meshheading:10447929-HIV Infections,
pubmed-meshheading:10447929-HIV-1,
pubmed-meshheading:10447929-Humans,
pubmed-meshheading:10447929-Male,
pubmed-meshheading:10447929-Middle Aged,
pubmed-meshheading:10447929-RNA, Viral,
pubmed-meshheading:10447929-Retrospective Studies,
pubmed-meshheading:10447929-Risk Factors,
pubmed-meshheading:10447929-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10447929-nef Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1999
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pubmed:articleTitle |
Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death.
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pubmed:affiliation |
Department of Infectious Diseases, Rigshospitalet, DK-2200 Copenhagen N, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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