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rdf:type |
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lifeskim:mentions |
umls-concept:C0011847,
umls-concept:C0012634,
umls-concept:C0032214,
umls-concept:C0035820,
umls-concept:C0085243,
umls-concept:C0123759,
umls-concept:C0205227,
umls-concept:C0600138,
umls-concept:C1306673,
umls-concept:C1554080,
umls-concept:C1706198
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-10
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pubmed:abstractText |
A rat monoclonal antibody (mAb) that neutralizes mouse interleukin-12 (IL-12) was administered to female non-obese diabetic (NOD) mice of different ages to dismantle the role of endogenous IL-12 in murine autoimmune diabetogenesis. This mAb was effective in preventing clinical, but not histological signs of spontaneous diabetes when treatment was started early in life at the age of 4 weeks and consecutively continued for 10 weeks. Delaying commencement of anti-IL-12 mAb prophylaxis until the age of 18 weeks, when NOD mice suffer from advanced insulitis, was ineffective. Anti-IL-12 mAb did not influence the course of the accelerated model of diabetes induced by cyclophosphamide. These data prove that the pathogenetic role of endogenous IL-12 in NOD mouse diabetes is restricted to the very early diabetogenic events presumably occurring prior to insulitis development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-1899431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-1909135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-7590817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-7595199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-7836934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-7988484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8056041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8095192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8168635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8181185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8558012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8590951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8720612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8933280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-8940385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9022080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9166662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9178025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9341777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9366391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9609135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9713328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9794448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10447755-9819366
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-2805
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10447755-Animals,
pubmed-meshheading:10447755-Antibodies, Monoclonal,
pubmed-meshheading:10447755-Autoimmune Diseases,
pubmed-meshheading:10447755-Diabetes Mellitus, Experimental,
pubmed-meshheading:10447755-Female,
pubmed-meshheading:10447755-Interleukin-12,
pubmed-meshheading:10447755-Mice,
pubmed-meshheading:10447755-Mice, Inbred NOD,
pubmed-meshheading:10447755-Rats
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pubmed:year |
1999
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pubmed:articleTitle |
Endogenous interleukin-12 only plays a key pathogenetic role in non-obese diabetic mouse diabetes during the very early stages of the disease.
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pubmed:affiliation |
Institute of Microbiology, University of Milan, Italy.
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pubmed:publicationType |
Journal Article
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