Source:http://linkedlifedata.com/resource/pubmed/id/10447326
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-10-21
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| pubmed:abstractText |
In order to characterize the impact and pattern of Gram-negative bacteraemia (GNB) at a Swiss University hospital and to assess the effect of multi-resistance on mortality, we conducted a 6-y retrospective cohort study using linear regression and multivariate Cox-proportional hazard analysis. 1766 patients had 1835 episodes of GNB; 61% were community-acquired. The incidence of GNB increased linearly (r2 = 0.90, p = 0.014) from 7.07 episodes to 8.32 episodes per 1000 admissions, but this trend was no longer significant after adjustment for the number of blood cultures drawn/y. The in-hospital mortality for patients with GNB decreased from 20% in 1989 to 16% in 1994 (r2 = 0.94, p = 0.005). The risk ratio for death remained unchanged over the study period and was 7-fold higher for patients with GNB than for patients without GNB. Factors independently associated with an increased hazard of death after GNB were: severity of illness as measured by exposure to intensive care (hazard ratio [HR], 1.5); age = 66-79 y (HR 1.8); GNB due to Klebsiella spp. (HR 1.7) or Pseudomonas aeruginosa (HR 1.6); and polymicrobial infection (HR 1.6). Multi-resistance was not associated with an increased risk of death (HR 1.0). Although the crude mortality of GNB decreased, the population-attributable risk ratio for death remained significant. These data suggest the absence of a major impact of multi-resistant GNB on patient mortality.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0036-5548
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
163-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10447326-Adult,
pubmed-meshheading:10447326-Aged,
pubmed-meshheading:10447326-Aged, 80 and over,
pubmed-meshheading:10447326-Anti-Bacterial Agents,
pubmed-meshheading:10447326-Bacteremia,
pubmed-meshheading:10447326-Cohort Studies,
pubmed-meshheading:10447326-Community-Acquired Infections,
pubmed-meshheading:10447326-Cross Infection,
pubmed-meshheading:10447326-Drug Resistance, Microbial,
pubmed-meshheading:10447326-Drug Resistance, Multiple,
pubmed-meshheading:10447326-Female,
pubmed-meshheading:10447326-Gram-Negative Bacteria,
pubmed-meshheading:10447326-Gram-Negative Bacterial Infections,
pubmed-meshheading:10447326-Hospitals, University,
pubmed-meshheading:10447326-Humans,
pubmed-meshheading:10447326-Linear Models,
pubmed-meshheading:10447326-Male,
pubmed-meshheading:10447326-Microbial Sensitivity Tests,
pubmed-meshheading:10447326-Middle Aged,
pubmed-meshheading:10447326-Proportional Hazards Models,
pubmed-meshheading:10447326-Retrospective Studies,
pubmed-meshheading:10447326-Survival Analysis,
pubmed-meshheading:10447326-Switzerland
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| pubmed:year |
1999
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| pubmed:articleTitle |
Impact and pattern of gram-negative bacteraemia during 6 y at a large university hospital.
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| pubmed:affiliation |
Infection Control Program, Geneva University Hospitals, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|