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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-8-30
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pubmed:abstractText |
Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1-HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the gene-specific targeting of Swi/Snf.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIR1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/HIR2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SNF2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/SNF5 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/SWI3 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10445029-Adenosine Triphosphatases,
pubmed-meshheading:10445029-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:10445029-DNA-Binding Proteins,
pubmed-meshheading:10445029-Evolution, Molecular,
pubmed-meshheading:10445029-Fungal Proteins,
pubmed-meshheading:10445029-Gene Expression Regulation, Fungal,
pubmed-meshheading:10445029-Histones,
pubmed-meshheading:10445029-Mutation,
pubmed-meshheading:10445029-Nuclear Proteins,
pubmed-meshheading:10445029-Promoter Regions, Genetic,
pubmed-meshheading:10445029-Repressor Proteins,
pubmed-meshheading:10445029-Saccharomyces cerevisiae,
pubmed-meshheading:10445029-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:10445029-Trans-Activators,
pubmed-meshheading:10445029-Transcription, Genetic,
pubmed-meshheading:10445029-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
A role for transcriptional repressors in targeting the yeast Swi/Snf complex.
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pubmed:affiliation |
Program in Molecular Biology, Sloan Kettering Cancer Center, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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