| pubmed-article:10444469 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10444469 | lifeskim:mentions | umls-concept:C0229889 | lld:lifeskim |
| pubmed-article:10444469 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:10444469 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10444469 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:10444469 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:10444469 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:10444469 | pubmed:dateCreated | 1999-9-23 | lld:pubmed |
| pubmed-article:10444469 | pubmed:abstractText | A mode of action of endothelin (ET) on spontaneous contractions was investigated in ring preparations of isolated bovine mesenteric lymphatics. ET-1 at concentrations between 10(-10) and 10(-9) M caused a dose-dependent increase in the frequency of spontaneous contractions. The specific ET(A)-receptor antagonist BQ-123 (5 x 10(-7) M) caused a significant inhibition of the ET-1-induced positive chronotropic effect in the ring preparations with and without the endothelium. Mechanical denudation of the lymphatic endothelial cells produced a significant potentiation of the ET-induced positive chronotropic effect. BQ-3020 (10(-8)-10(-7) M), a selective ET(B)-receptor agonist, induced dose dependently negative chronotropic and inotropic effects on the spontaneous contractions in the ring preparations with intact endothelium. Mechanical removal of the endothelium caused a significant reduction of the BQ-3020-induced negative chronotropic and inotropic effects. The ET-1-induced positive chronotropic effect was potentiated by pretreatment with N(omega)-nitro-L-arginine methyl ester (L-NAME) (10(-5) M) but unaffected by aspirin (10(-5) M). Additional treatment with L-arginine (10(-4) M) completely reversed the L-NAME-mediated potentiation of the ET-induced chronotropic effect. These results suggest that stimulation of ET(A) receptors on the lymphatic smooth muscles causes a positive chronotropic effect on the spontaneous contractions, and stimulation of ET(B) receptors on the lymphatic endothelial cells induces a release of nitric oxide, which results in the chronotropic and inotropic effects on spontaneous contractions in isolated bovine mesenteric lymphatics. | lld:pubmed |
| pubmed-article:10444469 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10444469 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10444469 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10444469 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10444469 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10444469 | pubmed:author | pubmed-author:OhhashiTT | lld:pubmed |
| pubmed-article:10444469 | pubmed:author | pubmed-author:SakaiHH | lld:pubmed |
| pubmed-article:10444469 | pubmed:author | pubmed-author:IkomaNN | lld:pubmed |
| pubmed-article:10444469 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10444469 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:10444469 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10444469 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10444469 | pubmed:pagination | H459-66 | lld:pubmed |
| pubmed-article:10444469 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10444469 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10444469 | pubmed:articleTitle | Effects of endothelin on spontaneous contractions in lymph vessels. | lld:pubmed |
| pubmed-article:10444469 | pubmed:affiliation | The First Department of Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan. | lld:pubmed |
| pubmed-article:10444469 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10444469 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10444469 | lld:pubmed |
