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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1999-12-29
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pubmed:abstractText |
The discovery of glycosylphosphatidylinositol (GPI) membrane anchors has had a significant impact on several areas of eukaryote cell biology. Studies of the African trypanosome, which expresses a dense surface coat of GPI-anchored variant surface glycoprotein, have played important roles in establishing the general structure of GPI membrane anchors and in delineating the pathway of GPI biosynthesis. The major cell-surface molecules of related parasites are also rich in GPI-anchored glycoproteins and/or GPI-related glycophospholipids, and differences in substrate specificity between enzymes of trypanosomal and mammalian GPI biosynthesis may have potential for the development of anti-parasite therapies. Apart from providing stable membrane anchorage, GPI anchors have been implicated in the sequestration of GPI-anchored proteins into specialised membrane microdomains, known as lipid rafts, and in signal transduction events.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9533
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
112 ( Pt 17)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2799-809
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10444375-Animals,
pubmed-meshheading:10444375-Dimerization,
pubmed-meshheading:10444375-Evolution, Molecular,
pubmed-meshheading:10444375-Glycosylation,
pubmed-meshheading:10444375-Glycosylphosphatidylinositols,
pubmed-meshheading:10444375-HeLa Cells,
pubmed-meshheading:10444375-Humans,
pubmed-meshheading:10444375-Leishmania,
pubmed-meshheading:10444375-Mammals,
pubmed-meshheading:10444375-Mannose,
pubmed-meshheading:10444375-Membrane Lipids,
pubmed-meshheading:10444375-Membrane Proteins,
pubmed-meshheading:10444375-Models, Molecular,
pubmed-meshheading:10444375-Protein Processing, Post-Translational,
pubmed-meshheading:10444375-Protozoan Proteins,
pubmed-meshheading:10444375-Signal Transduction,
pubmed-meshheading:10444375-Structure-Activity Relationship,
pubmed-meshheading:10444375-Trypanosoma brucei brucei,
pubmed-meshheading:10444375-Trypanosoma cruzi,
pubmed-meshheading:10444375-Variant Surface Glycoproteins, Trypanosoma,
pubmed-meshheading:10444375-Virulence
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pubmed:year |
1999
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pubmed:articleTitle |
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.
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pubmed:affiliation |
Division of Molecular Parasitology and Biological Chemistry, Department of Biochemistry, The Wellcome Trust Building, University of Dundee, Dundee DD1 5EH, UK. majferguson@bad.dundee.ac.uk
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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