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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
1999-9-14
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pubmed:abstractText |
Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-9564
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
569-75
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10443559-Adult,
pubmed-meshheading:10443559-Aged,
pubmed-meshheading:10443559-Aged, 80 and over,
pubmed-meshheading:10443559-Animals,
pubmed-meshheading:10443559-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10443559-Avoidance Learning,
pubmed-meshheading:10443559-Chemotaxis, Leukocyte,
pubmed-meshheading:10443559-Hot Temperature,
pubmed-meshheading:10443559-Humans,
pubmed-meshheading:10443559-Lithium Carbonate,
pubmed-meshheading:10443559-Lymphoma,
pubmed-meshheading:10443559-Lymphoproliferative Disorders,
pubmed-meshheading:10443559-Mice,
pubmed-meshheading:10443559-Middle Aged,
pubmed-meshheading:10443559-Multiple Myeloma,
pubmed-meshheading:10443559-Neurotoxins,
pubmed-meshheading:10443559-Peripheral Nervous System,
pubmed-meshheading:10443559-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10443559-Vincristine
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pubmed:year |
1999
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pubmed:articleTitle |
Is lithium able to reverse neurological damage induced by vinca alkaloids? (Short communication).
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pubmed:affiliation |
Oncology Department, University of Pisa, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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