Source:http://linkedlifedata.com/resource/pubmed/id/10441861
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-8-30
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pubmed:abstractText |
A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, "ASTA Medica", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy. 10 patients of the control group received a physiological solution stained with 1% solution of riboflavin mononucleate (B2 vitamin) as placebo. Intravenous infusion was administered once daily during a period of 3 weeks. Diabetic neuropathy score was assessed at the entry as well as on days 7, 14 and 21 of therapy. Indicators of lipid peroxidation (oxidative stress)--malonic dialdehyde levels in plasma and membranes of erythrocytes. Electroneuromyography were performed. Most of the patients (29) noted symptomatic improvement after 7-10 infusions and on day 14 a significant reduction of the diabetic neuropathy score was noted in comparison to a baseline (p < 0.05). The further improvement of clinical picture had been pronounced by day 21 (p < 0.001). Improvement of symptom score was obtained in 39 patients (97.5%). The response rate in the control group was 40%. Parameters of oxidative stress and electroneuromyography improved significantly in the main group of patients, while these in placebo group remained without changes.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos,
http://linkedlifedata.com/resource/pubmed/chemical/Thioctic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Tromethamine
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pubmed:status |
MEDLINE
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pubmed:issn |
1997-7298
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-22
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pubmed:dateRevised |
2008-3-31
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pubmed:meshHeading |
pubmed-meshheading:10441861-Analysis of Variance,
pubmed-meshheading:10441861-Blood Glucose,
pubmed-meshheading:10441861-Diabetes Mellitus, Type 2,
pubmed-meshheading:10441861-Diabetic Neuropathies,
pubmed-meshheading:10441861-Female,
pubmed-meshheading:10441861-Humans,
pubmed-meshheading:10441861-Hypoglycemic Agents,
pubmed-meshheading:10441861-Infusions, Intravenous,
pubmed-meshheading:10441861-Male,
pubmed-meshheading:10441861-Middle Aged,
pubmed-meshheading:10441861-Placebos,
pubmed-meshheading:10441861-Single-Blind Method,
pubmed-meshheading:10441861-Thioctic Acid,
pubmed-meshheading:10441861-Time Factors,
pubmed-meshheading:10441861-Tromethamine
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pubmed:year |
1999
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pubmed:articleTitle |
[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
English Abstract,
Randomized Controlled Trial
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