10441007

Source:http://linkedlifedata.com/resource/pubmed/id/10441007

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0029463, umls-concept:C0086418, umls-concept:C1335259, umls-concept:C1335494, umls-concept:C1521871
pubmed:issue	1
pubmed:dateCreated	1999-8-27
pubmed:abstractText	We studied the involvement of PRIM1 in osteosarcoma by differential display, Northern and Southern hybridization, as well as fluorescence in situ hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology specimens were tested. PRIM1 was found to be amplified in 41% of the samples. PRIM1 is coamplified with the core 12q13 amplicon genes CDK4, SAS, and OS9, and was physically mapped very close to them. PRIM1 is therefore a new candidate for the role of a major target gene of 12q13 amplifications in human cancers. Genes Chromosomes Cancer 26:62-69, 1999.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9007329
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/CDK4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primase, http://linkedlifedata.com/resource/pubmed/chemical/Lectins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/OS9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/TSPAN31 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tetraspanins
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1045-2257
pubmed:author	pubmed-author:BernsteinM LML, pubmed-author:ChampagneM AMA, pubmed-author:HamelHH, pubmed-author:LeclercJ MJM, pubmed-author:LevyEE, pubmed-author:RivardG EGE, pubmed-author:RussoP APA, pubmed-author:YotovW VWV
pubmed:copyrightInfo	Copyright 1999 Wiley-Liss, Inc.
pubmed:issnType	Print
pubmed:volume	26
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	62-9
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:10441007-Blotting, Northern, pubmed-meshheading:10441007-Bone Neoplasms, pubmed-meshheading:10441007-Chromosomes, Human, Pair 12, pubmed-meshheading:10441007-Cyclin-Dependent Kinase 4, pubmed-meshheading:10441007-Cyclin-Dependent Kinases, pubmed-meshheading:10441007-DNA, Neoplasm, pubmed-meshheading:10441007-DNA Primase, pubmed-meshheading:10441007-Gene Amplification, pubmed-meshheading:10441007-Gene Expression Regulation, Neoplastic, pubmed-meshheading:10441007-HeLa Cells, pubmed-meshheading:10441007-Humans, pubmed-meshheading:10441007-Hybrid Cells, pubmed-meshheading:10441007-In Situ Hybridization, Fluorescence, pubmed-meshheading:10441007-Lectins, pubmed-meshheading:10441007-Membrane Proteins, pubmed-meshheading:10441007-Neoplasm Proteins, pubmed-meshheading:10441007-Osteosarcoma, pubmed-meshheading:10441007-Physical Chromosome Mapping, pubmed-meshheading:10441007-Proto-Oncogene Proteins, pubmed-meshheading:10441007-RNA, Messenger, pubmed-meshheading:10441007-Tetraspanins, pubmed-meshheading:10441007-Tumor Cells, Cultured
pubmed:year	1999
pubmed:articleTitle	Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.
pubmed:affiliation	Département de Pédiatrie, Hôpital Ste-Justine, Université de Montréal, Montréal, Québec, Canada. yotovw@ere.umontreal.ca
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't