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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0013303,
umls-concept:C0017347,
umls-concept:C0030274,
umls-concept:C0033414,
umls-concept:C0040648,
umls-concept:C0044602,
umls-concept:C0061355,
umls-concept:C0330390,
umls-concept:C0442805,
umls-concept:C0598312,
umls-concept:C1148673,
umls-concept:C1414685,
umls-concept:C1515877,
umls-concept:C1826562,
umls-concept:C1879547,
umls-concept:C2266866
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pubmed:issue |
7
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pubmed:dateCreated |
1999-10-20
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pubmed:abstractText |
Glucagon-like peptide-1 is a potent glucoincretin hormone and a potentially important drug in the treatment of Type II (non-insulin-dependent) diabetes mellitus. We have investigated whether it acts as a growth factor in beta (INS-1)-cells and have studied the signalling pathways and transcription factors implicated in this process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nifedipine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
856-64
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10440129-Androstadienes,
pubmed-meshheading:10440129-Animals,
pubmed-meshheading:10440129-Chromones,
pubmed-meshheading:10440129-DNA,
pubmed-meshheading:10440129-DNA-Binding Proteins,
pubmed-meshheading:10440129-Duodenum,
pubmed-meshheading:10440129-Enzyme Activation,
pubmed-meshheading:10440129-Enzyme Inhibitors,
pubmed-meshheading:10440129-Genes, Homeobox,
pubmed-meshheading:10440129-Glucagon,
pubmed-meshheading:10440129-Glucagon-Like Peptide 1,
pubmed-meshheading:10440129-Glucose,
pubmed-meshheading:10440129-Humans,
pubmed-meshheading:10440129-Insulin,
pubmed-meshheading:10440129-Islets of Langerhans,
pubmed-meshheading:10440129-Morpholines,
pubmed-meshheading:10440129-Nifedipine,
pubmed-meshheading:10440129-Pancreas,
pubmed-meshheading:10440129-Peptide Fragments,
pubmed-meshheading:10440129-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:10440129-Potassium Chloride,
pubmed-meshheading:10440129-Protein Precursors,
pubmed-meshheading:10440129-RNA, Messenger,
pubmed-meshheading:10440129-Rats,
pubmed-meshheading:10440129-Rats, Wistar,
pubmed-meshheading:10440129-Signal Transduction,
pubmed-meshheading:10440129-Transcription Factor AP-1,
pubmed-meshheading:10440129-Transcription Factors,
pubmed-meshheading:10440129-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.
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pubmed:affiliation |
Department of Nutrition, University of Montreal and the CR-CHUM, Institute of Cancer, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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