| pubmed-article:10438976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0005767 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0559522 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:10438976 | lifeskim:mentions | umls-concept:C1621967 | lld:lifeskim |
| pubmed-article:10438976 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10438976 | pubmed:dateCreated | 1999-9-9 | lld:pubmed |
| pubmed-article:10438976 | pubmed:abstractText | Memory T cells that home to inflamed tissues typically express the beta-chemokine receptor CCR5 and exhibit a Th1 cytokine profile. The migration of these cells into the genital tract following antigenic exposure has particular relevance to acquisition of HIV-1 infection, because CCR5 functions as the coreceptor for most sexually transmitted HIV-1 strains. We recently established methodology to purify and culture mononuclear cells from the female reproductive tract, and here we analyzed the phenotype, CCR5 expression, and cytokine production of cervicovaginal T cells in up to 16 donors. The proportion of mucosal T cells expressing CCR5 was markedly expanded as compared with peripheral blood (mean 88% vs 24% in 13 donors), but the receptor density on individual CCR5+ T cells was only slightly increased (mean 5837 vs 4191 MEPE (molecules of equivalent PE) units in 6 of 7 donors). Intracellular costaining for IL-2, IFN-gamma, IL-4, and IL-5 revealed a Th1-type pattern in cervical T cells, with significantly higher percentages of IL-2- and IFN-gamma-producing T cells in the mucosa than in blood (mean 67% vs 29%). Coexpression of surface CCR5 with intracellular IL-2 and IFN-gamma was observed only among T cells in the mucosa, but not among those in circulation. Thus, we postulate that T cell homing to the genital mucosa leads to differentiation into the combined CCR5+ Th1 phenotype. Moreover, the predominance of CCR5+ Th1-type T cells in normal cervical mucosa provides targets accessible for the efficient transmission of macrophage-tropic HIV-1 variants in women following sexual exposure. | lld:pubmed |
| pubmed-article:10438976 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10438976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10438976 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10438976 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10438976 | pubmed:author | pubmed-author:McElrathM JMJ | lld:pubmed |
| pubmed-article:10438976 | pubmed:author | pubmed-author:McElroyAA | lld:pubmed |
| pubmed-article:10438976 | pubmed:author | pubmed-author:HladikFF | lld:pubmed |
| pubmed-article:10438976 | pubmed:author | pubmed-author:LentzGG | lld:pubmed |
| pubmed-article:10438976 | pubmed:author | pubmed-author:DelpitEE | lld:pubmed |
| pubmed-article:10438976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10438976 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10438976 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10438976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10438976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10438976 | pubmed:pagination | 2306-13 | lld:pubmed |
| pubmed-article:10438976 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10438976 | pubmed:meshHeading | pubmed-meshheading:10438976... | lld:pubmed |
| pubmed-article:10438976 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10438976 | pubmed:articleTitle | Coexpression of CCR5 and IL-2 in human genital but not blood T cells: implications for the ontogeny of the CCR5+ Th1 phenotype. | lld:pubmed |
| pubmed-article:10438976 | pubmed:affiliation | Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. | lld:pubmed |
| pubmed-article:10438976 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10438976 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10438976 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10438976 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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