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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-9-9
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pubmed:abstractText |
We show that macrophages of X-linked immunodeficient mice with a mutant nonfunctional Bruton's tyrosine kinase produce less NO than wild-type macrophages in response to a variety of stimuli. Induction of the inducible NO synthase (iNOS) protein, the transcription factor IFN regulatory factor-1 involved in iNOS expression, and the transcription factor STAT-1 involved in regulating IFN regulatory factor-1 induction are all poorer in X-linked immunodeficient than in wild-type macrophages. On the other hand, induction of IL-12 is higher in X-linked immunodeficient than in wild-type macrophages. Macrophage IL-12 induction is enhanced by iNOS inhibitors such as aminoguanidine and thiocitrulline and is inhibited by NO generation via sodium nitroprusside. There is relative enhancement of IFN-gamma production by immune T cells from mice immunized under aminoguanidine cover. Our data thus suggest that Bruton's tyrosine kinase participates in signaling for iNOS induction via IFN regulatory factor-1 in macrophages and that NO is an inhibitor of IL-12 induction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agammaglobulinaemia tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Conalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Irf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/pimagedine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1786-92
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:10438910-Animals,
pubmed-meshheading:10438910-Chickens,
pubmed-meshheading:10438910-Conalbumin,
pubmed-meshheading:10438910-DNA-Binding Proteins,
pubmed-meshheading:10438910-Enzyme Inhibitors,
pubmed-meshheading:10438910-Guanidines,
pubmed-meshheading:10438910-Immunologic Deficiency Syndromes,
pubmed-meshheading:10438910-Interferon Regulatory Factor-1,
pubmed-meshheading:10438910-Interleukin-12,
pubmed-meshheading:10438910-Lymphocyte Activation,
pubmed-meshheading:10438910-Macrophages, Peritoneal,
pubmed-meshheading:10438910-Mice,
pubmed-meshheading:10438910-Mice, Inbred CBA,
pubmed-meshheading:10438910-Mice, Mutant Strains,
pubmed-meshheading:10438910-Nitric Oxide,
pubmed-meshheading:10438910-Nitric Oxide Synthase,
pubmed-meshheading:10438910-Nitric Oxide Synthase Type II,
pubmed-meshheading:10438910-Phosphoproteins,
pubmed-meshheading:10438910-Protein-Tyrosine Kinases,
pubmed-meshheading:10438910-STAT1 Transcription Factor,
pubmed-meshheading:10438910-T-Lymphocytes,
pubmed-meshheading:10438910-Trans-Activators
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pubmed:year |
1999
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pubmed:articleTitle |
Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction.
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pubmed:affiliation |
National Institute of Immunology, New Delhi, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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