Source:http://linkedlifedata.com/resource/pubmed/id/10438379
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1999-9-23
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pubmed:abstractText |
Heterozygosity for a 32-bp deletion in the CCR5 gene (CCR5 Delta32), which encodes the coreceptor for macrophage-tropic non-syncytium-inducing (NSI) human immunodeficiency virus type 1 (HIV-1) variants, results in a lower CCR5 expression and reduced NSI HIV-1 replication. Because infection of macrophages and microglial cells by NSI HIV-1 is considered to be instrumental for the development of AIDS dementia complex (ADC), we studied whether the CCR5 Delta32 heterozygous genotype correlated with a reduced frequency of ADC. Two (4.1%) of 49 patients with ADC versus 27 (14. 5%) of 186 AIDS patients without ADC were heterozygous for CCR5 Delta32 (P=.05). In contrast, a point mutation in the first transmembrane domain of CCR2 (CCR2 64I) did not show this protective effect (P=.57). The reduced prevalence of the CCR5 Delta32 allele among patients with ADC may indicate a reduced or absent reservoir of macrophage-tropic NSI HIV-1 in the brain of CCR5 Delta32 heterozygotes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
854-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10438379-AIDS Dementia Complex,
pubmed-meshheading:10438379-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10438379-Brain,
pubmed-meshheading:10438379-Case-Control Studies,
pubmed-meshheading:10438379-Genotype,
pubmed-meshheading:10438379-HIV-1,
pubmed-meshheading:10438379-Heterozygote,
pubmed-meshheading:10438379-Homozygote,
pubmed-meshheading:10438379-Humans,
pubmed-meshheading:10438379-Macrophages,
pubmed-meshheading:10438379-Receptors, CCR5,
pubmed-meshheading:10438379-Sequence Deletion,
pubmed-meshheading:10438379-Virus Replication
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pubmed:year |
1999
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pubmed:articleTitle |
Reduced prevalence of the CCR5 delta32 heterozygous genotype in human immunodeficiency virus-infected individuals with AIDS dementia complex.
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pubmed:affiliation |
Department of Clinical Viro-Immunology, CLB, and the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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