| pubmed-article:10438362 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C0018483 | lld:lifeskim |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C0682576 | lld:lifeskim |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C0027442 | lld:lifeskim |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C0040284 | lld:lifeskim |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10438362 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10438362 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10438362 | pubmed:dateCreated | 1999-9-23 | lld:pubmed |
| pubmed-article:10438362 | pubmed:abstractText | A pair of isogenic, nontypeable Haemophilus influenzae strains, one expressing protein D and the other protein D-negative, was compared in their ability to cause damage in a human nasopharyngeal tissue culture model. Damage was assessed by measuring the ciliary beat frequency (CBF) of tissue specimens at 12 h intervals. Cultures inoculated with H. influenzae manifested a decrease in CBF beginning after 12 h, with a maximum decrease after 36 h. The impairment of ciliary function by the protein D-expressing strain was significantly greater than that caused by the protein D-negative mutant (P<.01). Tissue specimens examined by scanning and transmission electron microscopy after 24 h appeared normal. After 48 h of incubation, the protein D-expressing strain caused a significant loss of cilia. These findings suggest that protein D is involved in the pathogenesis of upper respiratory tract infections due to nontypeable H. influenzae, probably by enhancing functional and morphological damage to cilia. | lld:pubmed |
| pubmed-article:10438362 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10438362 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10438362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10438362 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10438362 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10438362 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:ForsgrenAA | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:LindbergSS | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:CervinAA | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:JansonHH | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:RunerTT | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:Carl nBB | lld:pubmed |
| pubmed-article:10438362 | pubmed:author | pubmed-author:MagnusdottirA... | lld:pubmed |
| pubmed-article:10438362 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10438362 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:10438362 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10438362 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10438362 | pubmed:pagination | 737-46 | lld:pubmed |
| pubmed-article:10438362 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
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| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:meshHeading | pubmed-meshheading:10438362... | lld:pubmed |
| pubmed-article:10438362 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10438362 | pubmed:articleTitle | Effects on the ciliated epithelium of protein D-producing and -nonproducing nontypeable Haemophilus influenzae in nasopharyngeal tissue cultures. | lld:pubmed |
| pubmed-article:10438362 | pubmed:affiliation | Department of Medical Microbiology, Lund University, University Hospital, Malmö, Sweden. | lld:pubmed |
| pubmed-article:10438362 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10438362 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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