Linked Life Data

10438320

Source:http://linkedlifedata.com/resource/pubmed/id/10438320

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pubmed-article:10438320pubmed:abstractTextThe effects of IL-12 on the responses of cattle peripheral blood mononuclear cells (PBMC) to bovine respiratory syncytial virus (BRSV) antigen and ovalbumin (OVA) were tested, in vitro. IL-12 did not affect the proliferative responses of PBMC to these antigens but markedly accelerated and augmented the level of IFNgamma secreted. When tested on lymphoblasts rather than resting T-cells IL-12 also enhanced proliferation. In contrast IL-4 and, to greater extent, IL-10 inhibited the response. The effect of IL-12 on IFNgamma synthesis was confirmed at the level of IFNgamma. mRNA expression using Taqman PCR. CD4 and CD8 T-cell populations produced IFNgamma, however, CD4 T-cells comprised the largest contributors to the IFNgamma production. Gamma/delta T-cells did not contribute markedly. A comparison of the species cross-reactivity showed bovine IL-12 was also active in the human system. This study shows that antigen-driven responses in cattle can be significantly influenced by exogenous cytokines and suggests the IL-12/IL-10 balance is crucial for regulation of IFNgamma.lld:pubmed
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pubmed-article:10438320pubmed:authorpubmed-author:CollinsR ARAlld:pubmed
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pubmed-article:10438320pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:10438320pubmed:articleTitleBovine interleukin-12 and modulation of IFNgamma production.lld:pubmed
pubmed-article:10438320pubmed:affiliationDivision of Immunology and Pathology, Institute for Animal Health, Newbury, Berkshire, UK. collinsr@bbsrc.ac.uklld:pubmed
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pubmed-article:10438320pubmed:publicationTypeComparative Studylld:pubmed
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