|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1999-8-16
|
|
pubmed:abstractText |
We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
455
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
364-6
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10437805-Adrenal Glands,
pubmed-meshheading:10437805-Adrenocorticotropic Hormone,
pubmed-meshheading:10437805-Aldosterone,
pubmed-meshheading:10437805-Angiotensin II,
pubmed-meshheading:10437805-Corticosterone,
pubmed-meshheading:10437805-Desoxycorticosterone,
pubmed-meshheading:10437805-Humans,
pubmed-meshheading:10437805-Kinetics,
pubmed-meshheading:10437805-Melanoma,
pubmed-meshheading:10437805-Progesterone,
pubmed-meshheading:10437805-Skin,
pubmed-meshheading:10437805-Tumor Cells, Cultured
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells.
|
|
pubmed:affiliation |
Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. aslomin@wpo.it.luc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
