Linked Life Data

10436054

Source:http://linkedlifedata.com/resource/pubmed/id/10436054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1999-9-1
pubmed:abstractText
The reelin and dab1 genes are necessary for appropriate neuronal migration and lamination during brain development. Since these processes are controlled by thyroid hormone, we studied the effect of thyroid hormone deprivation and administration on the expression of reelin and dab1. As shown by Northern analysis, in situ hybridization, and immunohistochemistry studies, hypothyroid rats expressed decreased levels of reelin RNA and protein during the perinatal period [embryonic day 18 (E18) and postnatal day 0 (P0)]. The effect was evident in Cajal-Retzius cells of cortex layer I, as well as in layers V/VI, hippocampus, and granular neurons of the cerebellum. At later ages, however, Reelin was more abundant in the cortex, hippocampus, cerebellum, and olfactory bulb of hypothyroid rats (P5), and no differences were detected at P15. Conversely, Dab1 levels were higher at P0, and lower at P5 in hypothyroid animals. In line with these results, reelin RNA and protein levels were higher in cultured hippocampal slices from P0 control rats compared to those from hypothyroid animals. Significantly, thyroid-dependent regulation of reelin and dab1 was confirmed in vivo and in vitro by hormone treatment of hypothyroid rats and organotypic cultures, respectively. In both cases, thyroid hormone led to an increase in reelin expression. Our data suggest that the effects of thyroid hormone on neuronal migration may be in part mediated through the control of reelin and dab1 expression during brain ontogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6979-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10436054-Animals, pubmed-meshheading:10436054-Animals, Newborn, pubmed-meshheading:10436054-Brain, pubmed-meshheading:10436054-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:10436054-Cell Movement, pubmed-meshheading:10436054-Cerebral Cortex, pubmed-meshheading:10436054-Down-Regulation, pubmed-meshheading:10436054-Embryonic and Fetal Development, pubmed-meshheading:10436054-Extracellular Matrix Proteins, pubmed-meshheading:10436054-Fungal Proteins, pubmed-meshheading:10436054-Gene Expression Regulation, Developmental, pubmed-meshheading:10436054-Hypothyroidism, pubmed-meshheading:10436054-Nerve Tissue Proteins, pubmed-meshheading:10436054-Neurons, pubmed-meshheading:10436054-Rats, pubmed-meshheading:10436054-Rats, Wistar, pubmed-meshheading:10436054-Serine Endopeptidases, pubmed-meshheading:10436054-Thyroid Hormones
pubmed:year
1999
pubmed:articleTitle
Thyroid hormone regulates reelin and dab1 expression during brain development.
pubmed:affiliation
Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't