Source:http://linkedlifedata.com/resource/pubmed/id/10435797
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1999-9-2
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| pubmed:abstractText |
One of three groups of sheep was challenged twice-weekly with infective-stage larvae (L3) of the sheep parasite O. circumcincta, another with the cattle parasite O. ostertagi while the third received no larval challenge. Positive faecal egg counts (FEC) and a rise in plasma pepsinogen levels were observed only in those animals given O. circumcincta. Anti-O. circumcincta L3 IgG titres were rapidly elevated during parasite challenge with either O. circumcincta or O. ostertagi. Throughout the experiment, no rise in anti-adult IgG titres or eosinophil numbers was observed in peripheral blood in any group. On evidence of self-cure of the trickle-infection, determined by a reduction in FEC, all groups were drenched and challenged with 15,000 O. circumcincta L3. No effect of previous challenge on parasite establishment or FEC was observed, although egg viability was significantly reduced in both groups given prior challenge. Significant differences in adult female worm length were observed between groups. Those recovered from animals previously challenged with O. circumcincta were shorter than from those given O. ostertagi which were in turn shorter than those from previously unchallenged animals. In utero egg counts were significantly lower in worms from animals previously challenged with O. circumcincta than in those from unchallenged control animals. The results indicate that a level of immunity to O. circumcincta can be conferred by exposure to O. ostertagi.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Albendazole,
http://linkedlifedata.com/resource/pubmed/chemical/Anthelmintics,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Levamisole,
http://linkedlifedata.com/resource/pubmed/chemical/Pepsinogen A
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0304-4017
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
84
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
125-35
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10435797-Abomasum,
pubmed-meshheading:10435797-Administration, Topical,
pubmed-meshheading:10435797-Albendazole,
pubmed-meshheading:10435797-Animals,
pubmed-meshheading:10435797-Anthelmintics,
pubmed-meshheading:10435797-Antibodies, Helminth,
pubmed-meshheading:10435797-Cattle,
pubmed-meshheading:10435797-Cattle Diseases,
pubmed-meshheading:10435797-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10435797-Eosinophils,
pubmed-meshheading:10435797-Feces,
pubmed-meshheading:10435797-Female,
pubmed-meshheading:10435797-Leukocyte Count,
pubmed-meshheading:10435797-Levamisole,
pubmed-meshheading:10435797-Male,
pubmed-meshheading:10435797-Ostertagia,
pubmed-meshheading:10435797-Ostertagiasis,
pubmed-meshheading:10435797-Parasite Egg Count,
pubmed-meshheading:10435797-Pepsinogen A,
pubmed-meshheading:10435797-Random Allocation,
pubmed-meshheading:10435797-Sheep,
pubmed-meshheading:10435797-Sheep Diseases
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| pubmed:year |
1999
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| pubmed:articleTitle |
The immune response of sheep to larval challenge with Ostertagia circumcincta and O. ostertagi.
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| pubmed:affiliation |
AgResearch, Grasslands, Palmerston North, New Zealand. sutherlandi@agresearch.cri.nz
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| pubmed:publicationType |
Journal Article
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