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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-8-11
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pubmed:abstractText |
Thymocytes are positively selected for alphabeta T cell antigen receptors (TCR) that recognize antigen in conjunction with self-major histocompatibility complex (MHC) molecules. MHC bound peptides participate in positive selection; however, their role has remained controversial. A TCR transgenic mouse was established using a TCR restricted to the MHC class Ib molecule, H2-M3. Having defined H2-M3 as the positively selecting MHC molecule, the severely limited number of H2-M3 binding peptides allowed us to characterize an NADH dehydrogenase subunit 1 (ND1)-derived peptide as the physiological ligand of positive selection. This peptide bears no apparent sequence homology to the cognate peptide, is expressed ubiquitously, and yet does not interfere with peripheral T cells. Our studies also suggest that positive selection becomes promiscuous at high epitope densities.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10435577-Animals,
pubmed-meshheading:10435577-Antigen Presentation,
pubmed-meshheading:10435577-Cell Line,
pubmed-meshheading:10435577-Crosses, Genetic,
pubmed-meshheading:10435577-Fetus,
pubmed-meshheading:10435577-H-2 Antigens,
pubmed-meshheading:10435577-Histocompatibility Antigens Class I,
pubmed-meshheading:10435577-Mice,
pubmed-meshheading:10435577-Mice, Inbred BALB C,
pubmed-meshheading:10435577-Mice, Inbred C57BL,
pubmed-meshheading:10435577-Mice, Knockout,
pubmed-meshheading:10435577-Mice, Transgenic,
pubmed-meshheading:10435577-N-Formylmethionine,
pubmed-meshheading:10435577-NADH Dehydrogenase,
pubmed-meshheading:10435577-Oligopeptides,
pubmed-meshheading:10435577-Organ Culture Techniques,
pubmed-meshheading:10435577-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10435577-T-Lymphocyte Subsets,
pubmed-meshheading:10435577-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Positive selection of an H2-M3 restricted T cell receptor.
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pubmed:affiliation |
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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